黄体生成素/绒毛膜促性腺激素受体

Luteinizing hormone/choriogonadotropin receptor 黄体生成素/绒毛膜促性腺激素受体
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1LUT, 1XUL
标识
代号	LHCGR; HHG; LCGR; LGR2; LH/CG-R; LH/CGR; LHR; LHRHR; LSH-R; ULG5
扩展标识	遗传学：152790 鼠基因：96783 同源基因：37276 IUPHAR:  LH ChEMBL: 1854 GeneCards: LHCGR Gene
基因本体论描述 分子功能 · luteinizing hormone receptor activity · choriogonadotropin hormone receptor activity · choriogonadotropin hormone binding 细胞成分 · endosome · plasma membrane · integral to plasma membrane 生物过程 · ovarian follicle development · G-protein coupled receptor signaling pathway · G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger · activation of adenylate cyclase activity · phospholipase C-activating G-protein coupled receptor signaling pathway · spermatogenesis · male gonad development · male genitalia development · positive regulation of inositol trisphosphate biosynthetic process · positive regulation of cAMP-mediated signaling · development of secondary male sexual characteristics · uterus development · cellular response to gonadotropin stimulus · seminiferous tubule development · regulation of steroid hormone biosynthetic process Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	3973	16867
Ensembl	ENSG00000138039	ENSMUSG00000024107
UniProt	P22888	P30730
mRNA序列	NM_000233	NM_013582
蛋白序列	NP_000224	NP_038610
基因位置	Chr 2: 48.86 – 48.98 Mb	Chr 17: 88.74 – 88.79 Mb
PubMed查询	[1]	[2]

黄体生成素/绒毛膜促性腺激素受体（英語：luteinizing hormone/choriogonadotropin receptor，缩写LHCGR也作 lutropin/choriogonadotropin receptor，LCGR或luteinizing hormone receptor，LHR ）是一种主要出现在卵巢和睾丸的跨膜受体，但在一些性腺外的器官如子宫和乳房也有表达。该受体是G蛋白偶联受体（GPCR）的一种，既能与黄体生成素（LH）互作也能与绒毛膜促性腺激素（如人类的hCG），其激活是在繁殖期间的荷尔蒙运作所需的。

LHCGR基因

LHCGR位于人类基因组上的2號染色體p21区，接近类似的促卵泡激素受体（FSHR）基因，长约70Kbp（FSHR为54Kpb），除了与FSHR相似外，还类似于促甲状腺激素受体（TSHR）。

历史

馬丁·羅德貝爾与艾爾佛列·古曼·吉爾曼因发现G蛋白系统而获得1994年的诺贝尔生理学或医学奖。

相互作用

黄体生成素/绒毛膜促性腺激素受体与GIPC1能进行相互作用。

延伸阅读

• Ji TH, Ryu KS, Gilchrist R, Ji I. Interaction, signal generation, signal divergence, and signal transduction of LH/CG and the receptor.. Recent Prog. Horm. Res. 1997, 52: 431–53; discussion 454. PMID 9238862. 
• Dufau ML. The luteinizing hormone receptor.. Annu. Rev. Physiol. 1998, 60: 461–96. PMID 9558473. doi:10.1146/annurev.physiol.60.1.461. 
• Ascoli M, Fanelli F, Segaloff DL. The lutropin/choriogonadotropin receptor, a 2002 perspective.. Endocr. Rev. 2002, 23 (2): 141–74. PMID 11943741. doi:10.1210/er.23.2.141. 
• Amsterdam A; Hanoch T; Dantes A; et al. Mechanisms of gonadotropin desensitization. Mol. Cell. Endocrinol. 2003, 187 (1–2): 69–74. PMID 11988313. doi:10.1016/S0303-7207(01)00701-8. 
• Fanelli F, Puett D. Structural aspects of luteinizing hormone receptor: information from molecular modeling and mutagenesis. Endocrine. 2003, 18 (3): 285–93. PMID 12450321. doi:10.1385/ENDO:18:3:285. 
• Latronico AC, Segaloff DL. Insights Learned from L457(3.43)R, an Activating Mutant of the Human Lutropin Receptor. Mol. Cell. Endocrinol. 2007,. 260-262: 287–93. PMC 1785107 . PMID 17055147. doi:10.1016/j.mce.2005.11.053. 
• Nagayama Y; Russo D; Wadsworth HL; et al. Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. J. Biol. Chem. 1991, 266 (23): 14926–30. PMID 1651314. 
• Jia XC; Oikawa M; Bo M; et al. Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species. Mol. Endocrinol. 1991, 5 (6): 759–68. PMID 1922095. doi:10.1210/mend-5-6-759. 
• Minegishi T; Nakamura K; Takakura Y; et al. Cloning and sequencing of human LH/hCG receptor cDNA. Biochem. Biophys. Res. Commun. 1990, 172 (3): 1049–54. PMID 2244890. doi:10.1016/0006-291X(90)91552-4. 
• Rousseau-Merck MF; Misrahi M; Atger M; et al. Localization of the human luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chromosome 2p21. Cytogenet. Cell Genet. 1991, 54 (1–2): 77–9. PMID 2249480. doi:10.1159/000132962. 
• Xie YB, Wang H, Segaloff DL. Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. J. Biol. Chem. 1991, 265 (35): 21411–4. PMID 2254302. 
• Frazier AL; Robbins LS; Stork PJ; et al. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol. Endocrinol. 1991, 4 (8): 1264–76. PMID 2293030. doi:10.1210/mend-4-8-1264. 
• Keutmann HT; Charlesworth MC; Mason KA; et al. A receptor-binding region in human choriogonadotropin/lutropin beta subunit. Proc. Natl. Acad. Sci. U.S.A. 1987, 84 (7): 2038–42. PMC 304579 . PMID 3470775. doi:10.1073/pnas.84.7.2038. 
• Jiang X, Dreano M, Buckler DR; et al. Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 1996, 3 (12): 1341–53. PMID 8747461. doi:10.1016/S0969-2126(01)00272-6.  引文格式1维护：显式使用等标签 (link)
• Atger M; Misrahi M; Sar S; et al. Structure of the human luteinizing hormone-choriogonadotropin receptor gene: unusual promoter and 5' non-coding regions. Mol. Cell. Endocrinol. 1995, 111 (2): 113–23. PMID 7556872. doi:10.1016/0303-7207(95)03557-N. 
• Latronico AC; Anasti J; Arnhold IJ; et al. A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty. J. Clin. Endocrinol. Metab. 1995, 80 (8): 2490–4. PMID 7629248. doi:10.1210/jc.80.8.2490. 
• Shenker A; Laue L; Kosugi S; et al. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature. 1993, 365 (6447): 652–4. PMID 7692306. doi:10.1038/365652a0. 
• Yano K; Saji M; Hidaka A; et al. A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty. J. Clin. Endocrinol. Metab. 1995, 80 (4): 1162–8. PMID 7714085. doi:10.1210/jc.80.4.1162. 
• Kremer H; Kraaij R; Toledo SP; et al. Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nat. Genet. 1995, 9 (2): 160–4. PMID 7719343. doi:10.1038/ng0295-160. 
• Kosugi S; Van Dop C; Geffner ME; et al. Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty. Hum. Mol. Genet. 1995, 4 (2): 183–8. PMID 7757065. doi:10.1093/hmg/4.2.183. 
• Kremer H; Mariman E; Otten BJ; et al. Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty. Hum. Mol. Genet. 1994, 2 (11): 1779–83. PMID 8281137. doi:10.1093/hmg/2.11.1779. 

外部链接

• Glycoprotein Hormone Receptors: LH. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2021-01-18）. 
• GRIS: Glycoprotein-hormone Receptor Information System
• 醫學主題詞表（MeSH）：LH-hCG+Receptors