咪唑并[4,5-f][1,10]菲啰啉

咪唑并[4,5-f][1,10]菲啰啉
英文名	1H-Imidazo[4,5-f][1,10]phenanthroline
别名	1H-咪唑并[4,5-f][1,10]菲啰啉; IPM713
识别
CAS号	171565-43-8
性质
化学式	C13H8N4
摩尔质量	220.23 g·mol⁻¹
外观	白色固体
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

咪唑并[4,5-f][1,10]菲啰啉是一种有机化合物，化学式为C₁₃H₈N₄。它可由1,10-菲啰啉-5,6-二酮、甲醛、乙酸铵和冰乙酸在惰性气氛中回流反应得到，它经水稀释后，用氨水调节pH至中性后析出。^[1]它和2-碘丙烷在碳酸铯存在下于乙腈中反应，可以得到1-异丙基咪唑并[4,5-f][1,10]菲啰啉。^[2]很多金属可以和其菲啰啉氮配位，形成配位化合物。^[3]^[4]

参考文献

^ Shujian Hu, Wantong Ma, Junyi Wang, Zhongkun Zhou, Yunhao Ma, Rentao Zhang, Kangjia Du, Hao Zhang, Mengze Sun, Xinrong Jiang, Hongyuan Tu, Xiaoliang Tang, Xiaojun Yao, Peng Chen. Synthesis and biological activity of 1H-imidazo[4,5-f][1,10]phenanthroline as a potential antitumor agent with PI3K/AKT/mTOR signaling. European Journal of Pharmacology. 2022-01, 915: 174514 [2022-05-16]. doi:10.1016/j.ejphar.2021.174514 （英语）.
^ James W. Pearson, Riley T. Endean, Loorthuraja Rasu, Steven H. Bergens. Investigation into the properties of a ruthenium(polypyridyl)-NHC compound. Canadian Journal of Chemistry. 2021-02, 99 (2): 230–235 [2022-05-16]. ISSN 0008-4042. doi:10.1139/cjc-2020-0397. （原始内容存档于2022-05-16）（英语）.
^ Guang-Bo Che, Shan-Shan Wang, Xiao-Lin Zha, Xiu-Ying Li, Chun-Bo Liu, Xing-Jing Zhang, Zhan-Lin Xu, Qing-Wei Wang. Syntheses, structures, and photoluminescence of a series of d10 coordination complexes from N,N′-bidentate imidazo[4,5-f][1,10]phenanthroline and benzene-1,3,5-tricarboxylic acid. Inorganica Chimica Acta. 2013-01, 394: 481–487 [2022-05-16]. doi:10.1016/j.ica.2012.09.007. （原始内容存档于2020-02-21）（英语）.
^ Lütfiye Gök, Salih Günnaz, Zarife Sibel Şahin, Levent Pelit, Hayati Türkmen. The imidazo{[4,5-f][1,10]-phenanthrolin}l-2-ylidene and its palladium complexes: Synthesis, characterization, and application in C-C cross-coupling reactions. Journal of Organometallic Chemistry. 2017-01, 827: 96–104 [2022-05-16]. doi:10.1016/j.jorganchem.2016.11.013. （原始内容存档于2020-03-02）（英语）.

参见

mTOR抑制剂（英语：mTOR inhibitors）

[1] Shujian Hu, Wantong Ma, Junyi Wang, Zhongkun Zhou, Yunhao Ma, Rentao Zhang, Kangjia Du, Hao Zhang, Mengze Sun, Xinrong Jiang, Hongyuan Tu, Xiaoliang Tang, Xiaojun Yao, Peng Chen. Synthesis and biological activity of 1H-imidazo[4,5-f][1,10]phenanthroline as a potential antitumor agent with PI3K/AKT/mTOR signaling. European Journal of Pharmacology. 2022-01, 915: 174514 [2022-05-16]. doi:10.1016/j.ejphar.2021.174514 （英语）.

[2] James W. Pearson, Riley T. Endean, Loorthuraja Rasu, Steven H. Bergens. Investigation into the properties of a ruthenium(polypyridyl)-NHC compound. Canadian Journal of Chemistry. 2021-02, 99 (2): 230–235 [2022-05-16]. ISSN 0008-4042. doi:10.1139/cjc-2020-0397. （原始内容存档于2022-05-16）（英语）.

[3] Guang-Bo Che, Shan-Shan Wang, Xiao-Lin Zha, Xiu-Ying Li, Chun-Bo Liu, Xing-Jing Zhang, Zhan-Lin Xu, Qing-Wei Wang. Syntheses, structures, and photoluminescence of a series of d10 coordination complexes from N,N′-bidentate imidazo[4,5-f][1,10]phenanthroline and benzene-1,3,5-tricarboxylic acid. Inorganica Chimica Acta. 2013-01, 394: 481–487 [2022-05-16]. doi:10.1016/j.ica.2012.09.007. （原始内容存档于2020-02-21）（英语）.

[4] Lütfiye Gök, Salih Günnaz, Zarife Sibel Şahin, Levent Pelit, Hayati Türkmen. The imidazo{[4,5-f][1,10]-phenanthrolin}l-2-ylidene and its palladium complexes: Synthesis, characterization, and application in C-C cross-coupling reactions. Journal of Organometallic Chemistry. 2017-01, 827: 96–104 [2022-05-16]. doi:10.1016/j.jorganchem.2016.11.013. （原始内容存档于2020-03-02）（英语）.

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