雙乙基己氧基苯酚甲氧基苯三嗪
雙乙基己氧基苯酚甲氧基苯三嗪 | |
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IUPAC名 2,2′-[6-(4-methoxyphenyl)- 1,3,5-triazine-2,4-diyl] bis{5-[(2-ethylhexyl)oxy]phenol} | |
別名 | Tinosorb S Bis-ethylhexyloxyphenol methoxyphenyl triazine Anisotriazine |
識別 | |
縮寫 | BEMT |
CAS號 | 187393-00-6 ![]() |
ChemSpider | 10645286 |
SMILES |
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InChI |
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InChIKey | XVAMCHGMPYWHNL-UHFFFAOYAK |
性質 | |
化學式 | C38H49N3O5 |
摩爾質量 | 627.81 g/mol g·mol⁻¹ |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
Bemotrizinol (INN[1][2]/USAN[3]名稱;INCN名稱,bis-ethylhexyloxyphenol methoxyphenyl triazine)是一種油溶性的有機化合物,添加於防曬乳中吸收紫外線。BASF與 Ashland Inc分別以商品名 Tinosorb S及Escalol S推出上市。Bemotrizinol是廣域性(寬頻)的紫外線吸收劑,能吸收 UVB以至UVA,它的吸收頂峰有兩個,分別位於波長 310及 340奈米處。[4] 其光穩定性極高,即使施予 50MEDs(minimal erythema doses,最小曬紅劑量,其數值因人而異。例如某人照射 20分鐘的紫外線皮膚即出現紅腫現象,20分鐘則為其最小曬紅劑量)之紫外線,仍能保有 98.4%的量不被分解, 與其他防曬劑例如阿伏苯宗混合還能抑制它們產生光分解反應(photodegradation)[5]
Bemotrizinol不受美國 FDA核可。2000年後陸續獲得歐盟與澳大利亞等核准。[6] [7] [8] 與其他有機(化學)防曬劑不同的是,它於活體外實驗(In vitro)之中不會呈現出雌激素效應。[9]
參考資料
- ^ 存档副本 (PDF). [2013-06-25]. (原始內容存檔 (PDF)於2012-02-11).
- ^ 存档副本 (PDF). [2013-06-25]. (原始內容存檔 (PDF)於2012-02-11).
- ^ 存档副本. [2013-06-25]. (原始內容存檔於2007-09-29).
- ^ Vielhaber G, Grether-Beck S, Koch O, Johncock W, Krutmann J. Sunscreens with an absorption maximum of > or =360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts. Photochem Photobiol Sci. March 2006, 5 (3): 275–82. PMID 16520862. doi:10.1039/b516702g.
- ^ Chatelain E, Gabard B. Photostabilization of Butyl methoxydibenzoylmethane (Avobenzone) and Ethylhexyl methoxycinnamate by Bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. September 2001, 74 (3): 401–6. PMID 11594052. doi:10.1562/0031-8655(2001)074<0401:POBMAA>2.0.CO;2.
- ^ .SpringerLink - Journal Article[永久失效連結]
- ^ NEW-WAVE SUNSCREENS: Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions, Chemical & Engineering News, April 11, 2005, Volume 83, Number 15, pp. 18–22. Online version (頁面存檔備份,存於網際網路檔案館)
- ^ Australian Regulatory Guidelines for OTC Medicines - Chapter 10 (PDF). [2013-06-25]. (原始內容 (PDF)存檔於2007-08-31).
- ^ Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA. Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S. Regul Toxicol Pharmacol. December 2001, 34 (3): 287–91. PMID 11754532. doi:10.1006/rtph.2001.1511.