細胞色素 P450 27A1(英語:Cytochrome P450 27A1,縮寫CYP27A1)也被稱為甾醇-27-羥化酶(sterol 27-hydroxylase,EC 1.14.15.15),是細胞色素P450超家族的一員,由CYP27A1基因編碼,是定位於許多不同組織線粒體內膜的單加氧酶,能催化多種甾醇側鏈上27號位以及其它位置的羥基化,如在膽汁酸合成中催化膽固醇生成27-羥基膽固醇[6],在維生素D合成代謝中催化膽鈣化醇(維生素D3)生成骨化二醇(25-羥基維生素D3)[7]。
參考文獻
- ^ 與CYP27A1相關的疾病;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000135929 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026170 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chiang JY. Regulation of bile acid synthesis. Frontiers in Bioscience. February 1998, 3 ( ): d176–93. PMID 9450986. doi:10.2741/a273.
- ^ Gascon-Barré, M; Demers, C; Ghrab, O; Theodoropoulos, C; Lapointe, R; Jones, G; Valiquette, L; Ménard, D. Expression of CYP27A, a gene encoding a vitamin D-25 hydroxylase in human liver and kidney.. Clinical endocrinology. 2001-01, 54 (1): 107–15. PMID 11167933. doi:10.1046/j.1365-2265.2001.01160.x.
外部連結
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| CYP1 | |
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| CYP2 | |
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| CYP3 | |
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| CYP4 | |
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| CYP5-20 | |
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| CYP21-49 | |
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| CYP51-69 | |
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| CYP101-281 | |
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| CYP301-499 | |
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