鴨嘴花鹼
鴨嘴花鹼 | |
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IUPAC名 1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol | |
別名 | Peganine |
識別 | |
CAS號 | 6159-56-4 ![]() |
PubChem | 72610 |
SMILES |
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性質 | |
化學式 | C11H12N2O |
摩爾質量 | 188.23 g·mol−1 |
熔點 | 210 °C(483 K) |
溶解性(丙酮、酒精、氯仿) | 易溶 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
鴨嘴花鹼(英語:Vasicine或peganine)是一種喹唑啉生物鹼。它被發現於鴨嘴花(Adhatoda vasica),並以此命名。它還存在於駱駝蓬中。[1]
鴨嘴花鹼也被和茶鹼在體外和體內進行了比較。[2]鴨嘴花鹼與類似物鴨嘴花鹼酮的組合也被進行了研究。兩種生物鹼的組合(1:1)在體內和體外均顯示出顯着的支氣管擴張活性。[3]這兩種生物鹼也是呼吸興奮劑。[3]鴨嘴花鹼具有心臟抑制作用,鴨嘴花鹼酮是一種弱心臟興奮劑;通過結合這兩種生物鹼可以使效果正常化。[3][4]據報道,鴨嘴花鹼具有子宮興奮作用。[4]
氨溴索是一種廣泛使用的溶分泌劑,由鴨嘴花鹼開發而成,可抑制人類肥大細胞和嗜鹼性粒細胞(過敏性炎症的主要效應物)分泌IgE依賴性介質。與鴨嘴花鹼相比,氨溴索在降低嗜鹼性粒細胞IL-4和IL-13分泌方面表現出更大的效果。[5][6]
參考資料
- ^ Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. July 2013, 7 (14): 199–212. PMC 3841998
. PMID 24347928. doi:10.4103/0973-7847.120524
.
- ^ Nepali, Kunal; Sharma, Sahil; Ojha, Ritu; Dhar, Kanaya Lal. Vasicine and structurally related quinazolines. Medicinal Chemistry Research. 2012, 22 (1): 1–15. ISSN 1054-2523. S2CID 253636554. doi:10.1007/s00044-012-0002-5.
- ^ 3.0 3.1 3.2 Avula, B.; et al. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis (PDF). Die Pharmazie. 2008, 63 (1): 20–22. PMID 18271297. doi:10.1691/ph.2008.7175.
- ^ 4.0 4.1 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 2008, 70 (1): 36–42. ISSN 0250-474X. PMC 2852058
. PMID 20390078. doi:10.4103/0250-474X.40329
.
- ^ Vasicine - an overview | ScienceDirect Topics. www.sciencedirect.com. [2024-03-03].
- ^ Gibbs, B. F. Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues. International Journal of Immunopathology and Pharmacology. 2009, 22 (4). ISSN 0394-6320. PMID 20074455. doi:10.1177/039463200902200407.