烟酸盐酸盐

烟酸盐酸盐
英文名	Nicotinic acid hydrochloride; Niacin hydrochloride
别名	3-吡啶甲酸盐酸盐
识别
CAS号	636-79-3
SMILES	OC(=O)c1c[nH+]ccc1.[Cl-];
性质
化学式	C6H6ClNO2
摩尔质量	159.57 g·mol−1
外观	晶体
熔点	250—255 °C（523—528 K）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

烟酸盐酸盐是一种化合物，化学式为C₆H₆ClNO₂，它由质子化的烟酸阳离子（C₆H₆NO₂⁺）和氯离子构成，分子间存在O－H…Cl、N－H…O和N－H…Cl氢键。^[2]它可由烟酸的甲醇溶液和盐酸的甲醇溶液反应得到。^[2]它可以在铂的催化下于50 °C加压氢化，得到3-哌啶甲酸盐酸盐。^[3]

参考文献

^ Wibaut, J. P.; Beyerman, H. C. The constitution of dihydronicotyrine (N-methylmyosmine). Recueil des Travaux Chimiques des Pays-Bas et de la Belgique, 1951. 70: 977-984. ISSN: 0370-7539.
^ ^2.0 ^2.1 Slouf, Miroslav. 3-Carboxypyridinium chloride. Acta Crystallographica Section E Structure Reports Online. 2000, 57 (1): o61–o62. ISSN 1600-5368. doi:10.1107/S1600536800019632.
^ Karpov, A. A.; Krasnikov, S. V.; Betnev, A. F.; Krasovskaya, G. G.; Chal'tsev, A. V. Catalytic hydrogenation of 2-furan- and 2- and 3-pyridinecarboxylic acids. Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya, 2007. 4: 44-46. ISSN: 0579-2991.
^ Yoshino, Teruo; Inaba, Shigeru; Komura, Hajime; Ishido, Yoshiharu. Synthetic Studies by the Use of Carbonates. I. The Nucleophilic Substitution Reaction of Ethylene Carbonate with Amine Hydrohalides. Bulletin of the Chemical Society of Japan. 1974, 47 (2): 405–409. ISSN 0009-2673. doi:10.1246/bcsj.47.405.
^ Goher, Mohamed A. S.; Mautner, Franz A.; Mak, Thomas C. W.; Abu-Youssef, Morsy A. M. Synthesis and Crystal Structures of [(Nicotinic Acid)2H]+I−, [(2-Amino-6-methylpyridine)H]+(NO3)?, and the 1:1 Complex Between 1-Isoquinoline Carboxylic Acid (Zwitter Ion) and L-Ascorbic Acid Assembled via Hydrogen Bonds. Monatshefte für Chemie / Chemical Monthly. 2003, 134 (12): 1519–1527. ISSN 0026-9247. doi:10.1007/s00706-003-0054-9.

[1] Wibaut, J. P.; Beyerman, H. C. The constitution of dihydronicotyrine (N-methylmyosmine). Recueil des Travaux Chimiques des Pays-Bas et de la Belgique, 1951. 70: 977-984. ISSN: 0370-7539.

[Slouf2000-2] 2.0 ^2.1 Slouf, Miroslav. 3-Carboxypyridinium chloride. Acta Crystallographica Section E Structure Reports Online. 2000, 57 (1): o61–o62. ISSN 1600-5368. doi:10.1107/S1600536800019632.

[3] Karpov, A. A.; Krasnikov, S. V.; Betnev, A. F.; Krasovskaya, G. G.; Chal'tsev, A. V. Catalytic hydrogenation of 2-furan- and 2- and 3-pyridinecarboxylic acids. Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya, 2007. 4: 44-46. ISSN: 0579-2991.

[4] Yoshino, Teruo; Inaba, Shigeru; Komura, Hajime; Ishido, Yoshiharu. Synthetic Studies by the Use of Carbonates. I. The Nucleophilic Substitution Reaction of Ethylene Carbonate with Amine Hydrohalides. Bulletin of the Chemical Society of Japan. 1974, 47 (2): 405–409. ISSN 0009-2673. doi:10.1246/bcsj.47.405.

[5] Goher, Mohamed A. S.; Mautner, Franz A.; Mak, Thomas C. W.; Abu-Youssef, Morsy A. M. Synthesis and Crystal Structures of [(Nicotinic Acid)2H]+I−, [(2-Amino-6-methylpyridine)H]+(NO3)?, and the 1:1 Complex Between 1-Isoquinoline Carboxylic Acid (Zwitter Ion) and L-Ascorbic Acid Assembled via Hydrogen Bonds. Monatshefte für Chemie / Chemical Monthly. 2003, 134 (12): 1519–1527. ISSN 0026-9247. doi:10.1007/s00706-003-0054-9.

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相关物质

参考文献