RNA酶III (Ribonuclease III,簡稱RNase III或RNase C[ 1] ,BRENDA 編號:3.1.26.3 (页面存档备份 ,存于互联网档案馆 ))為一類RNA酶 ,屬切割雙股RNA 的內切酶 ,均具有RNA酶III結構域 [ 2] 。此類RNA酶參與rRNA 、SnRNA 、SnoRNA 與miRNA 等RNA的生成過程[ 3] ,可在細胞中的特定位置切割這些RNA的前驅物以產生成熟的RNA[ 4] [ 5] 。三域 生物與部分病毒 皆具有RNA酶III。
RNA酶III可依結構域分為四型[ 6] 。切割miRNA前驅物的Drosha 與Dicer 分別屬於三型與四型的RNA酶III[ 7] [ 8]
參考文獻
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^ Zamore, Phollip D. Thirty-Three Years Later, a Glimpse at the Ribonuclease III Active Site. Molecular Cell. December 2001, 8 (6): 1158–1160. PMID 11885596 . doi:10.1016/S1097-2765(01)00418-X .
^ Inada, T.; Nakamura, Y. Lethal double-stranded RNA processing activity of ribonuclease III in the absence of SuhB protein of Escherichia coli . Biochimie. 1995, 77 (4): 294–302. PMID 8589060 . doi:10.1016/0300-9084(96)88139-9 .
^ Park, Hongmarn; Yakhnin, Helen; Connolly, Michael; Romeo, Tony; Babitzke, Paul; Gourse, R. L. CsrA Participates in a PNPase Autoregulatory Mechanism by Selectively Repressing Translation of Transcripts That Have Been Previously Processed by RNase III and PNPase . Journal of Bacteriology. 15 December 2015, 197 (24): 3751–3759. PMC 4652041 . PMID 26438818 . doi:10.1128/JB.00721-15 .
^ Liang YH, Lavoie M, Comeau MA, Abou Elela S, Ji X. Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection. . Mol Cell. 2014, 54 (3): 431–44. PMC 4019767 . PMID 24703949 . doi:10.1016/j.molcel.2014.03.006 .
^ Filippov V, Solovyev V, Filippova M, Gill SS. A novel type of RNase III family proteins in eukaryotes. Gene. Mar 2000, 245 (1): 213–221. PMID 10713462 . doi:10.1016/S0378-1119(99)00571-5 .
^ Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference. . Nature. 2001, 409 (6818): 363–6. PMID 11201747 . doi:10.1038/35053110 .