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信号转导接头蛋白

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Src相关接头蛋白Skap2

信号转导接头蛋白信号转导衔接蛋白(英語:Signal transducing adaptor proteins)是信号转导通路中的重要蛋白质。接头蛋白上有着各种能与其它蛋白结合的结构域,能形成各种信号复合体。这些蛋白质往往本身缺乏酶的活性[1],而是通过特异性的蛋白-蛋白交互作用形成蛋白质复合体来激活下游信号通路。常见的接头蛋白有MyD88Grb2SHC1等。

基因

编码接头蛋白的基因有:

  • BCAR3 – Breast cancer anti-estrogen resistance protein 3
  • GRAP – GRB2-related adaptor protein
  • GRAP2 – GRB2-related adaptor protein 2
  • LDLRAP1 – low-density lipoprotein receptor adaptor protein 1
  • NCK1 – NCK adaptor protein 1
  • NCK2 – NCK adaptor protein 2
  • NOS1AP – nitric oxide synthase 1 (neuronal) adaptor protein
  • PIK3AP1 – phosphoinositide-3-kinase adaptor protein 1
  • SH2B1 – SH2B adaptor protein 1
  • SH2B2 – SH2B adaptor protein 2
  • SH2B3 – SH2B adaptor protein 3
  • SH2D3A -SH2 domain containing 3A
  • SH2D3C – SH2 domain containing 3C
  • SHB – Src homology 2 domain containing adaptor protein B
  • SLC4A1AP – solute carrier family 4 (anion exchanger), member 1, adaptor protein
  • GAB2 – GRB2-associated binding protein 2

参考文献

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