原生质球

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显微镜下观察到的大肠杆菌原生质球

原生质球Spheroplast)是指细菌酵母,或真菌细胞失去部分细胞壁后,其余部分在表面张力作用下形成的球状体。原生质球对渗透压敏感,置于低渗透压溶液中,原生质球将会破裂[1][2]

原生质球可用于抗生素的筛选中。如果某一种细菌经药物处理后,可观察到原生质球的形成,就能推定这种药物能抑制该菌的细胞壁合成[3]

参考资料

  1. ^ Miller-Keane. spheroplast. Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health Seventh Edition. 2003. ISBN 978-1455726240. 
  2. ^ J. M. GEBICKI; A. M. JAMES. The Preparation and Properties of Spheroplasts of Aerobacter aerogenes (PDF). J. gen. Microbiol. 1960, (23): 9–18 [2018-12-27]. 
  3. ^ Silver, L.L. Rational approaches to antibiotic discovery: pre-genomic directed and phenotypic screening, 2.4.2 Screens for spheroplast formation. In: Thomas Dougherty, Michael J. Pucci, Antibiotic Discovery and Development. Chap. 2, p. 46.