跳转到内容

1,4-二(三氟甲基)苯

维基百科,自由的百科全书
1,4-二(三氟甲基)苯
别名 对二三氟甲苯
α,α,α,α',α',α'-六氟对二甲苯
识别
CAS号 433-19-2  checkY
SMILES
 
  • FC(F)(F)c1ccc(cc1)C(F)(F)F
性质
化学式 C8H4F6
摩尔质量 214.11 g·mol−1
熔点 115—117 °C(388—390 K)[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

1,4-二(三氟甲基)苯是一种有机化合物,化学式为C8H4F6。它可由4-三氟甲基苯硼酸三氟甲基亚铜(或其配合物[2])反应制得。[3]三氟乙酸钠也可作为三氟甲基化试剂与对三氟甲基碘苯反应,得到1,4-二(三氟甲基)苯。[4]它在硫酸-三氟乙酸中回流后加入NBS反应,可以得到1,4-二溴-2,5-二(三氟甲基)苯。[5]它和三溴化硼四氯化碳中反应,可以得到1,4-二(三溴甲基)苯。[6]

参考文献

  1. ^ Yagupol'skii, L. M.; Shein, S. M.; Krasnosel'skaya, M. I.; Solodushenkov, S. N. Preparation of 2-amino-4-trifluoromethylbenzoic acid. Zhurnal Obshchei Khimii, 1965. 35 (7): 1261-1263. ISSN: 0044-460X.
  2. ^ John Wiley & Sons. E-EROS encyclopedia of reagents for organic synthesis. Hoboken, NJ. [1999]-. ISBN 978-0-470-84289-8. OCLC 48998476. 
  3. ^ Hiroki Serizawa, Kohsuke Aikawa, Koichi Mikami. Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation. Chemistry - A European Journal. 2013-12-23, 19 (52): 17692–17697 [2020-10-22]. doi:10.1002/chem.201303828 (英语). 
  4. ^ Carr, G. E.; Chambers, R. D.; Holmes, T. F.; Parker, D. G. ChemInform Abstract: Sodium Perfluoroalkane Carboxylates as Sources of Perfluoroalkyl Groups.. ChemInform. 1988-07-26, 19 (30) [2022-10-01]. doi:10.1002/chin.198830124. (原始内容存档于2022-10-04) (英语). 
  5. ^ Devic, Thomas; Horcajada, Patricia; Serre, Christian; Salles, Fabrice; Maurin, Guillaume; Moulin, Béatrice; Heurtaux, Daniela; Clet, Guillaume; Vimont, Alexandre; Grenèche, Jean-Marc; Ouay, Benjamin Le. Functionalization in Flexible Porous Solids: Effects on the Pore Opening and the Host−Guest Interactions. Journal of the American Chemical Society. 2010-01-27, 132 (3) [2020-10-22]. ISSN 0002-7863. doi:10.1021/ja9092715. (原始内容存档于2020-10-08) (英语). 
  6. ^ Chen, Hongbiao; Yin, Jianxiang; Lin, Yuanbin. Mild and efficient conversion of trifluoromethylarenes into tribromomethylarenes using boron tribromide. Chemical Papers. 2009-01-01, 63 (1) [2022-10-01]. ISSN 1336-9075. doi:10.2478/s11696-008-0082-3. (原始内容存档于2022-10-04).