1-(2-联苯基)哌嗪

**1-(2-联苯基)哌嗪**
识别信息
	IUPAC命名法 1-(2-diphenyl)piperazine; ;
CAS号	180698-18-4
PubChem CID	2737389;
ChemSpider	2019031 ;
UNII	T5S5265H6V;
ChEMBL	ChEMBL494675 ;
化学信息
化学式	C16H18N2
摩尔质量	238.33 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C3CNCCN3c1ccccc1-c2ccccc2;
	InChI InChI=1S/C16H18N2/c1-2-6-14(7-3-1)15-8-4-5-9-16(15)18-12-10-17-11-13-18/h1-9,17H,10-13H2 ; Key:RKRVRTJVCWZOQS-UHFFFAOYSA-N ;

1-(2-联苯基)哌嗪是一种有机化合物，化学式为C₁₆H₁₈N₂。它可由1-叔丁氧羰基-4-(2-溴苯基)哌嗪和苯硼酸在四(三苯基膦)钯催化下反应制得，^[1]或由2-氨基联苯和二(氯乙基)胺盐酸盐在碳酸钾和碘化钾存在下反应得到。^[2]它和N-苄基-6-溴己酰胺在碳酸钾存在下于乙腈中回流反应，可以得到N-苄基-(4-联苯-2-基)哌嗪己酰胺。^[3]

参考文献

^ Yu, Maolin; Daniels, Matthew H.; Harmange, Jean-Christophe P.; Tibbitts, Thomas T.; Ledeboer, Mark W.; Walsh, Liron; Mundel, Peter H.; Malojcic, Goran. Pyridazinone derivatives in the treatment of disease and their preparation. 2019 WO 2019055966 A2.
^ Stefania Porcu, Stefania Demuro, Alberto Luridiana, Andrea Cocco, Angelo Frongia, David J. Aitken, Florence Charnay-Pouget, Regis Guillot, Giorgia Sarais, Francesco Secci. Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans. Organic Letters. 2018-12-07, 20 (23): 7699–7702 [2022-03-05]. ISSN 1523-7060. doi:10.1021/acs.orglett.8b03429. （原始内容存档于2022-03-05）（英语）.
^ Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone. Structural Modifications of N -(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT 7 Receptor Activity. Part III. Journal of Medicinal Chemistry. 2008-09-25, 51 (18): 5813–5822 [2022-03-05]. ISSN 0022-2623. doi:10.1021/jm800615e. （原始内容存档于2022-03-05）（英语）.

[1] Yu, Maolin; Daniels, Matthew H.; Harmange, Jean-Christophe P.; Tibbitts, Thomas T.; Ledeboer, Mark W.; Walsh, Liron; Mundel, Peter H.; Malojcic, Goran. Pyridazinone derivatives in the treatment of disease and their preparation. 2019 WO 2019055966 A2.

[2] Stefania Porcu, Stefania Demuro, Alberto Luridiana, Andrea Cocco, Angelo Frongia, David J. Aitken, Florence Charnay-Pouget, Regis Guillot, Giorgia Sarais, Francesco Secci. Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans. Organic Letters. 2018-12-07, 20 (23): 7699–7702 [2022-03-05]. ISSN 1523-7060. doi:10.1021/acs.orglett.8b03429. （原始内容存档于2022-03-05）（英语）.

[3] Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone. Structural Modifications of N -(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT 7 Receptor Activity. Part III. Journal of Medicinal Chemistry. 2008-09-25, 51 (18): 5813–5822 [2022-03-05]. ISSN 0022-2623. doi:10.1021/jm800615e. （原始内容存档于2022-03-05）（英语）.

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