2-乙酰氧基-5-氟苯甲酸
| 2-乙酰氧基-5-氟苯甲酸 | |
|---|---|
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| 识别 | |
| CAS号 | 448-40-8 
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| SMILES |
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| 性质 | |
| 化学式 | C9H7FO4 |
| 摩尔质量 | 198.15 g·mol−1 |
| 熔点 | 130.5 °C（403.6 K）[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
2-乙酰氧基-5-氟苯甲酸是一种有机化合物，化学式为C9H7O4F。
制备
2-羟基-5-氟苯甲酸和乙酸酐反应，可以制得2-乙酰氧基-5-氟苯甲酸。[2][3]
性质
2-乙酰氧基-5-氟苯甲酸和氯化亚砜在DMF的存在下于二氯甲烷溶剂中反应，可以得到2-乙酰氧基-5-氟苯甲酰氯。[4]它和2-氨基-5-硝基噻唑及PyBOP在一定条件下反应，生成2-羟基-5-氟-N-(5-硝基-2-噻唑氨基)苯甲酰胺。[2]
参考文献
- ^ Giuseppe Ciampa. Anhydrides of pharmacological interest. I. Synthesis and properties of symmetrical anhydrides of 2-acetoxy-5-halobenzoic acid（意大利文）. Annali di Chimica (Rome, Italy), 1964. 54 (10): 975-986. ISSN: 0003-4592.
- ^ 2.0 2.1 Joshua Odingo, Mai A. Bailey, Megan Files, Julie V. Early, Torey Alling, Devon Dennison, Julie Bowman, Suryakanta Dalai, Naresh Kumar, Jeffrey Cramer, Thierry Masquelin, Philip A. Hipskind, Tanya Parish. In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis. ACS Omega. 2017-09-30, 2 (9): 5873–5890 [2019-10-18]. ISSN 2470-1343. PMC 6044914
. PMID 30023755. doi:10.1021/acsomega.7b00892. （原始内容存档于2021-05-25） （英语）.
- ^ Berkessel, Albrecht; Krueger, Mark; Kreuzer, Karl-Anton; Poll-Wolbeck, Simon. Preparation of phenylbenzoate derivatives and analogs for use as antitumor agents. PCT Int. Appl., 2015. WO 2015044177 A1.
- ^ Sakamoto, Kathleen Miho; Smith, Mark; Chae, Hee-Don; Mitton, Bryan; Cox, Nicholas Raymond. Inhibitors of CREB-CBP interaction for treatment of leukemia. PCT Int. Appl., 2017. WO 2017156489 A1.
