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3-氯丙酸

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3-氯丙酸
识别信息
  • 3-chloropropionic acid
CAS号107-94-8  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.003.214 編輯維基數據鏈接
化学信息
化学式C3H5ClO2
摩尔质量108.52 g·mol−1
3D模型(JSmol英语JSmol
熔点42 °C(108 °F)
沸点204 °C(399 °F) (分解)
  • C(CCl)C(=O)O
  • InChI=1S/C3H5ClO2/c4-2-1-3(5)6/h1-2H2,(H,5,6)
  • Key:QEYMMOKECZBKAC-UHFFFAOYSA-N

3-氯丙酸是一种有机化合物,化学式为ClCH2CH2CO2H,它是无色或白色固体,可用作药物或合成中间体,它可由丙烯酸氯化氢反应制得。[1]

它和三苯基膦甲苯中回流反应,可以得到三苯基羧乙基氯化𬭸。[2]三氟甲磺酸的存在下,它和1,3-苯二酚加热反应,可以得到3-氯-1-(2,4-二羟基苯基)-1-丙酮。[3]

参考文献

  1. ^ Samel, Ulf-Rainer; Kohler, Walter; Gamer, Armin Otto; Keuser, Ullrich, Propionic Acid and Derivatives, Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, 2005, doi:10.1002/14356007.a22_223 
  2. ^ Céline Constant-Urban, Mounia Charif, Eric Goffin, Jean-Claude Van Heugen, Benaïssa Elmoualij, Patrice Chiap, Ange Mouithys-Mickalad, Didier Serteyn, Philippe Lebrun, Bernard Pirotte, Pascal De Tullio. Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic & Medicinal Chemistry Letters. 2013-11, 23 (21): 5878–5881 [2021-10-25]. doi:10.1016/j.bmcl.2013.08.091. (原始内容存档于2018-06-24) (英语). 
  3. ^ Lanying Zhao, Yueshan Li, Yujiao Wang, Zeen Qiao, Zhuang Miao, Jiao Yang, Luyi Huang, Chenyu Tian, Linli Li, Danian Chen, Shengyong Yang. Discovery of 4 H -Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models. Journal of Medicinal Chemistry. 2019-12-12, 62 (23): 10691–10710 [2021-10-25]. ISSN 0022-2623. doi:10.1021/acs.jmedchem.9b01143. (原始内容存档于2021-10-25) (英语).