3-碘类甲腺质

3-碘类甲腺质
	IUPAC名; 4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol
别名	T1AM
识别
CAS号	712349-95-6
PubChem	9950514
ChemSpider	8126125
SMILES	OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1;
InChI	1/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2;
InChIKey	XIINYOJWNGOUPF-UHFFFAOYAJ
性质
化学式	C14H14INO2
摩尔质量	355.17 g/mol g·mol⁻¹
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

3-类甲腺质，英文：3-Iodothyronamine（T₁AM）是一种内源性类甲腺质。T₁AM是痕量胺相关受体TAAR1（TAR1, TA1）的高亲和力配体，而TAAR1是一种G蛋白偶联受体。^[1]^[2]T₁AM是迄今为止发现的最有效的内源性TAAR1激动剂。^[3]T₁AM对TAAR1的激活导致产生大量cAMP。这种影响伴随体温和心输出量的下降。^[4]这种关系不是典型的内分泌系统关系，表明TAAR1活性可能不会与某些组织中的G蛋白发生偶联，或T₁AM可能与其他受体亚型相互作用。^[3]

由于3-类甲腺质可诱导负性肌力作用并降低心输出量，T₁AM可能是调节心脏信号通路功能的一部分。 ^[5]

参见

<i id="mwKg">O-</i>苯基-3-碘酪胺
微量胺

参考

^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. S2CID 2389946. doi:10.1038/nm1051.
^ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.
^ ^3.0 ^3.1 Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate Pathways of Thyroid Hormone Metabolism. Thyroid. 2005, 15 (8): 943–958. PMID 16131336. doi:10.1089/thy.2005.15.943.
^ New compound may act to keep thyroid activity in check. [2008-05-30]. （原始内容存档于2021-02-27）.
^ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. The FASEB Journal. 2007, 21 (7): 1597–608. PMID 17284482. S2CID 14015560. doi:10.1096/fj.06-7474com.

外部链接

醫學主題詞表（MeSH）：3-iodothyronamine

Template:Phenethylamines

[1] Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. S2CID 2389946. doi:10.1038/nm1051.

[2] Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.

[Wu-3] 3.0 ^3.1 Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate Pathways of Thyroid Hormone Metabolism. Thyroid. 2005, 15 (8): 943–958. PMID 16131336. doi:10.1089/thy.2005.15.943.

[4] New compound may act to keep thyroid activity in check. [2008-05-30]. （原始内容存档于2021-02-27）.

[5] Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. The FASEB Journal. 2007, 21 (7): 1597–608. PMID 17284482. S2CID 14015560. doi:10.1096/fj.06-7474com.

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