CD2

CD2
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1CDB、1GYA、1HNF、1L2Z、1QA9、2J6O、2J7I
識別號
别名	CD2；, LFA-2, SRBC, T11, CD2 molecule
外部ID	OMIM：186990 MGI：88320 HomoloGene：1338 GeneCards：CD2
基因位置（人类）
染色体	1號染色體
终止	116,769,229 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	101,195,255 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• protein homodimerization activity; • 血浆蛋白结合; • signaling receptor binding; • signaling receptor activity; • antigen binding; • protein kinase binding; • receptor tyrosine kinase binding; • 蛋白質自締合;
細胞組分	• integral component of membrane; • 膜; • cell-cell junction; • anchored component of plasma membrane; • integral component of plasma membrane; • 細胞外區域; • cell surface; • cytoplasmic side of plasma membrane; • external side of plasma membrane; • 细胞膜; • 大分子复合体; • 脂筏模型;
生物學過程	• positive regulation of myeloid dendritic cell activation; • heterotypic cell-cell adhesion; • natural killer cell activation; • membrane raft polarization; • cell surface receptor signaling pathway; • 細胞粘附; • positive regulation of tumor necrosis factor production; • T细胞活化; • leukocyte migration; • regulation of T cell differentiation; • 细胞凋亡; • cell-cell adhesion;
	Sources:Amigo / QuickGO
直系同源
	914
	12481
	ENSG00000116824
	ENSMUSG00000027863
	P06729; Q53F96
	P08920
	NM_001767; NM_001328609
	NM_013486
	NP_001315538; NP_001758; NP_001758.2
	NP_038514
	維基數據
檢視/編輯人類	檢視/編輯小鼠

CD2（分化簇2，英語：cluster of differentiation 2）是一个细胞黏附分子，是T细胞和自然杀伤细胞（NK细胞）共有的细胞表面标志物，也称为“T细胞表面抗原T11”（T-cell surface antigen T11）、LFA-2、LFA-3受体、“红细胞受体”（erythrocyte receptor）等^[5]^[6]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000116824 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027863 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982, 79 (23): 7489–93. Bibcode:1982PNAS...79.7489S. PMC 347365 . PMID 6984191. doi:10.1073/pnas.79.23.7489 .
^ Uniprot database entry for CD2 (accession number P06729)

外部链接

醫學主題詞表（MeSH）：CD2+Antigen
Mouse CD Antigen Chart
Human CD Antigen Chart
Human CD2 genome location and CD2 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000116824 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027863 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982, 79 (23): 7489–93. Bibcode:1982PNAS...79.7489S. PMC 347365 . PMID 6984191. doi:10.1073/pnas.79.23.7489 .

[6] Uniprot database entry for CD2 (accession number P06729)

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