GRL-0617 |
| 识别信息 |
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5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
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| CAS号 | 1093070-16-6  Y |
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| 化学信息 |
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| 化学式 | C20H20N2O |
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| 摩尔质量 | 304.39 g·mol−1 |
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| 3D模型（JSmol） | |
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CC1=C(C=C(C=C1)N)C(=O)N[C@H](C)C2=CC=CC3=CC=CC=C32
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InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1 Key:UVERBUNNCOKGNZ-CQSZACIVSA-N
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GRL-0617是一种药物，是最早被发现可作为木瓜蛋白酶样蛋白酶的选择性小分子抑制剂的化合物之一，它可在某些致病病毒（包括冠状病毒SARS-CoV-2）中发现。它已被证明可以在体外抑制病毒复制。[1][2][3][4]
参见
参考文献
- ^ Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, et al. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. November 2020, 587 (7835): 657–662. Bibcode:2020Natur.587..657S. PMC 7116779
. PMID 32726803. doi:10.1038/s41586-020-2601-5.
- ^ Hajbabaie R, Harper MT, Rahman T. Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like Protease (PDF). Molecules. February 2021, 26 (4): 1134 [2022-12-12]. PMC 7924369 . PMID 33672721. doi:10.3390/molecules26041134 . （原始内容存档 (PDF)于2022-12-12）.
- ^ Lim CT, Tan KW, Wu M, Ulferts R, Armstrong LA, Ozono E, et al. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. The Biochemical Journal. July 2021, 478 (13): 2517–2531. PMC 8286840 . PMID 34198325. doi:10.1042/BCJ20210244.
- ^ Xiang R, Yu Z, Wang Y, Wang L, Huo S, Li Y, et al. Recent advances in developing small-molecule inhibitors against SARS-CoV-2. Acta Pharmaceutica Sinica. B. July 2021. PMC 8260826 . PMID 34249607. doi:10.1016/j.apsb.2021.06.016.
