18-甲氧基冠狗牙花定碱

18-甲氧基冠狗牙花定碱
INN： Zolunicant
临床资料
其他名称	18-MC; Zolunicant; MM-110; MM110
给药途径	Oral
法律规范状态
法律规范	美：IND (filed 2/9/2014);
识别信息
	IUPAC命名法 methyl (1S,15R,17R,18S)-17-(2-methoxyethyl)-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate; ;
CAS号	308123-60-6 ; 188125-42-0
PubChem CID	10248465;
ChemSpider	24721799 ;
UNII	KX8NQX91Z8; racemic: VG463BM9RL ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID40437331 ;
化学信息
化学式	C22H28N2O3
摩尔质量	368.48 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES COCC[C@H]1C[C@@H]2C[C@@]3([C@H]1N(C2)CCc4c3[nH]c5c4cccc5)C(=O)OC;
	InChI InChI=1S/C22H28N2O3/c1-26-10-8-15-11-14-12-22(21(25)27-2)19-17(7-9-24(13-14)20(15)22)16-5-3-4-6-18(16)23-19/h3-6,14-15,20,23H,7-13H2,1-2H3/t14-,15+,20+,22-/m1/s1 ; Key:DTJQBBHYRQYDEG-SVBQBFEESA-N ;

18-甲氧基冠狗牙花定碱（英语：18-Methoxycoronaridine，缩写18-MC，开发代号：MM-110），或叫佐鲁尼坎（INN：zolunicant），是一种有机化合物，分子式C₂₂H₂₈N₂O₃，属于伊波加因的衍生物，1996年被开发为药物。^[1]^[2]

参考文献

^ Glick SD, Kuehne ME, Maisonneuve IM, Bandarage UK, Molinari HH. 18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats. Brain Research. May 1996, 719 (1–2): 29–35. PMID 8782860. S2CID 6178161. doi:10.1016/0006-8993(96)00056-X.
^ Glick SD, Sell EM, Maisonneuve IM. Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration. European Journal of Pharmacology. December 2008, 599 (1–3): 91–5. PMC 2600595 . PMID 18930043. doi:10.1016/j.ejphar.2008.09.038.

[1] Glick SD, Kuehne ME, Maisonneuve IM, Bandarage UK, Molinari HH. 18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats. Brain Research. May 1996, 719 (1–2): 29–35. PMID 8782860. S2CID 6178161. doi:10.1016/0006-8993(96)00056-X.

[2] Glick SD, Sell EM, Maisonneuve IM. Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration. European Journal of Pharmacology. December 2008, 599 (1–3): 91–5. PMC 2600595 . PMID 18930043. doi:10.1016/j.ejphar.2008.09.038.

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