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21-脱氧皮质醇

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21-脱氧皮质醇
IUPAC名
(8S,9S,10R,11S,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
别名 21-Desoxycortisol; 21-Dehydrohydrocortisone; 21-Deoxyhydrocortisone; 11β,17α-Dihydroxyprogesterone; 11β,17α-Dihydroxypregn-4-ene-3,20-dione
识别
CAS号 641-77-0  checkY
PubChem 92827
ChemSpider 83796
SMILES
 
  • CC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)O
ChEBI 28697
KEGG C05497
性质
化学式 C21H30O4
摩尔质量 346.46 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

21-脱氧皮质醇(英语:21-Deoxycortisol,也称为11β,17α-二羟基孕酮,11β,17α-dihydroxyprogesterone,或11β,17α-二羟基孕-4-烯-3,20-二酮,11β,17α-dihydroxypregn-4-ene-3,20-dione)是一种与皮质醇(11β,17α,21-三羟基孕酮)有关的天然内源甾体物质,可由类固醇11-β-羟化酶英语Steroid 11-beta-hydroxylase(CYP11B1)代谢17α-羟孕酮生成[1]

参考文献

  1. ^ Cristoni S, Cuccato D, Sciannamblo M, Bernardi LR, Biunno I, Gerthoux P, Russo G, Weber G, Mora S. Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoring. Rapid Commun. Mass Spectrom. 2004, 18 (1): 77–82. Bibcode:2004RCMS...18...77C. PMID 14689562. doi:10.1002/rcm.1284. 

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