N-(5-硝基-2-吡啶基)乙二胺
| N-(5-硝基-2-吡啶基)乙二胺 | |
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| 識別 | |
| CAS號 | 29602-39-9 
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| PubChem | 122425 |
| SMILES |
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| 性質 | |
| 化學式 | C7H10N4O2 |
| 摩爾質量 | 182.18 g·mol−1 |
| 熔點 | 123 °C（396 K） |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
N-(5-硝基-2-吡啶基)乙二胺是一種有機化合物，化學式為C7H10N4O2。它可由2-氯-5-硝基吡啶（或2-溴-5-硝基吡啶[1]）和乙二胺在乙腈中反應製得。[2]它和鄰苯二甲酸酐在三乙胺存在下於甲苯中回流，可以得到1,2,3,9b-四氫-1-(5-硝基-2-吡啶基)-5H-咪唑並[2,1-a]異吲哚-5-酮。[3]
參考文獻
- ^ Nonpeptide Somatostatin Agonists with sst4 Selectivity: Synthesis and Structure-Activity Relationships of Thioureas. Journal of Medicinal Chemistry (1998), 41(24), 4693-4705. doi:10.1021/jm980118e
- ^ Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3. Journal of Medicinal Chemistry (2017), 60(20), 8482-8514. doi:10.1021/acs.jmedchem.7b00922.
- ^ Cul, Armelle; Daich, Adam; Decroix, Bernard; Sanz, Gerard; Van Hijfte, Luc. Kinetic versus thermodynamic access to imidazoisoindolones, benzimidazoisoindolones, and [1,4]diazepinoisoindolones: intramolecular nitrogen and π-aromatic trapping of N-acyliminium cation. Tetrahedron. 2004. doi:10.1016/j.tet.2004.07.107.