SIB-1553A
SIB-1553A | |
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IUPAC名 4-{[2-(1-Methylpyrrolidin-2-yl)ethyl]sulfanyl}phenol | |
別名 | SIB 1553A 4-[2-(1-甲基-2-吡咯烷基)乙硫基]苯酚 |
識別 | |
CAS號 | 191611-76-4 ![]() |
PubChem | 5310968 |
ChemSpider | 4470512 |
SMILES |
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InChI |
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InChIKey | NVZGJSVPOOILDI-UHFFFAOYAV |
性質 | |
化學式 | C13H19NOS |
摩爾質量 | 237.36 g·mol−1 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
SIB-1553A是一種煙鹼型乙酰膽鹼受體激動劑,對CHRNB4(β4)受體有選擇性。在帕金森氏症模型中,給藥可改善記憶力與注意力。[1]
它可由2-(2-氯乙基)-1-甲基四氫吡咯和4-羥基苯硫酚在碳酸鉀存在下於DMF中反應得到。它和鹽酸反應得到SIB-1553A鹽酸鹽(CAS 191611-89-9)。[2]
參考文獻
- ^ Schneider, JS. The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys. Journal of Pharmacology and Experimental Therapeutics. July 2003, 306 (1): 401–6. PMID 12721323. S2CID 7060934. doi:10.1124/jpet.103.051912.
- ^ {{cite journal|journal=Journal of Medicinal Chemistry|volume=42|issue=10|language=en|issn=0022-2623|date=1999-05-01|pages=1684–1686|doi=10.1021/jm990035d|url=https://pubs.acs.org/doi/10.1021/jm990035d%7Ctitle=4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]- phenol Hydrochloride (SIB-1553A): A Novel Cognitive Enhancer with Selectivity for Neuronal Nicotinic Acetylcholine Receptors|accessdate=2022-10-04|author=Jean-Michel Vernier, Hassan El-Abdellaoui, Heather Holsenback, Nicholas D. P. Cosford, Leo Bleicher, Geoffrey Barker, Bruno Bontempi, Laura Chavez-Noriega, Frederique Menzaghi, Tadimeti S. Rao, Richard Reid, Aida I. Sacaan, Carla Suto, Mark Washburn, G. Kenneth Lloyd, Ian A. McDonald|archive-date=2022-10-06|archive-url=https://web.archive.org/web/20221006212635/https://pubs.acs.org/doi/10.1021/jm990035d%7Cdead-url=no}}
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