Daf-2
| abnormal dauer formation protein 2 | |
|---|---|
| 标识 | |
| 生物 | |
| 符号 | daf-2 |
| Entrez | 175410 |
| RefSeq （mRNA） | NM_065249.5 |
| RefSeq （蛋白质） | NP_497650.4 |
| UniProt | Q968Y9 |
| 其他数据 | |
| 染色体 | III: 2.99 - 3.03 Mb |
DAF-2是秀丽隐杆线虫（Caenorhabditis elegans）的一个基因，编码的蛋白与人胰岛素样生长因子1受体（IGF-1R）同源。DAF-2是第一个发现的与老化速率有关的代谢途径基因[1]。DAF-2也与生殖发育的调控，氧化应激的应对，温度耐受，缺氧以及对细菌病原体的抵抗有关[2]。辛西娅·凯尼恩（Cynthia Kenyon）获得的DAF-2突变体线虫寿命为普通线虫的两倍[3]。
参考文献
- ^ Keyton, C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.
- ^ Minaxi S Gami and Catherine A Wolkow (2006).
- ^ Jennie B. Dorman, Bella Albinder, Terry Shroyer & Cynthia Kenyon, "The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans," Genetics, volume 141, number 4, pages 1399-1406 (1995); and Javier Apfeld & Cynthia Kenyon, "Cell non-autonomy of C. elegans daf-2 function in the regulation of diapause and lifespan," Cell, v. 95, n.2, pp.199-210 (1998).