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RBL-1

维基百科,自由的百科全书
RBL-1细胞

RBL-1(Rat Basophilic Leukemia cells[1])是大鼠嗜碱性粒细胞性白血病英语Acute basophilic leukemia细胞系。由于RBL-1细胞对免疫球蛋白E及其FCER1英语FCER1受体的强烈反应,因此被用于研究过敏反应,并且因为它们在组织培养中具有更高的稳定性,因此它们被用于代替肥大细胞[2]。同时,RBL细胞有助于对人类患者进行过敏性研究[3][4]霉浆菌感染极大地影响了生物测定中细胞介体的释放。由于细菌会在RBL-1细胞的表面上生长,并且无法通过光学显微镜对其进行观察,因此需要进行常规的支原体检测。

参考资料

  1. ^ Bingham, B.R.; Monk, P.N.; Helm, B.A. Defective Protein Phosphorylation and Ca2+ Mobilization Linowa SecretingVariant of the Rat Basophilic Leukemia Cell Line. The Journal of Biological Chemistry. 1994, 269 (30): 19300–19306. 
  2. ^ Wang, Weimin; et al. Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells (PDF). Pharmacological Reports. 2012, (64): 1216–1222 [2020-01-08]. ISSN 1734-1140. (原始内容存档 (PDF)于2017-07-05). 
  3. ^ Yoo, JM; Sok, DE; Kim, MR. Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.. Journal of medicinal food. 2014-01, 17 (1): 92–102 [2020-01-08]. PMID 24456359. doi:10.1089/jmf.2013.2927. [永久失效链接]
  4. ^ Falcone, FH; Alcocer, MJ; Okamoto-Uchida, Y; Nakamura, R. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal?. Current allergy and asthma reports. 2015-11, 15 (11): 67 [2020-01-08]. PMID 26452547. doi:10.1007/s11882-015-0568-3. [永久失效链接]

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