产热素

产热素
识别号
别名	UCP1；, SLC25A7, UCP, uncoupling protein 1
外部ID	OMIM：113730 MGI：98894 HomoloGene：22524 GeneCards：UCP1
基因位置（人类）
染色体	4号染色体
终止	140,568,961 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	84,025,081 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• transmembrane transporter activity; • purine ribonucleotide binding; • long-chain fatty acid binding; • cardiolipin binding; • oxidative phosphorylation uncoupler activity;
细胞组分	• mitochondrial envelope; • 膜; • 线粒体; • mitochondrial membranes; • mitochondrial inner membrane; • integral component of membrane;
生物学过程	• regulation of transcription by RNA polymerase II; • brown fat cell differentiation; • diet induced thermogenesis; • ion transport; • response to temperature stimulus; • response to nutrient levels; • cellular response to hormone stimulus; • cellular response to reactive oxygen species; • cellular response to fatty acid; • regulation of reactive oxygen species biosynthetic process; • response to cold; • mitochondrial transmembrane transport; • adaptive thermogenesis; • mitochondrial transport; • proton transmembrane transport; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	7350
	22227
	ENSG00000109424
	ENSMUSG00000031710
	P25874
	P12242
	NM_021833
	NM_009463
	NP_068605
	NP_033489
	维基数据
查看/编辑人类	查看/编辑小鼠

产热素（Thermogenin），被发现者称为解偶联蛋白，现在称为解偶联蛋白1（UCP1）^[5]是在棕色脂肪组织（BAT）线粒体中发现的解偶联蛋白。它用于通过不发抖的生热（英语：Thermogenesis）来产生热量，并且在定量上对抵抗婴儿的热量损失做出了重要的贡献，否则由于高表面积-体积比，会发生热量损失。

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000109424 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031710 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: UCP1 uncoupling protein 1 (mitochondrial, proton carrier). （原始内容存档于2018-10-23）.

外部链接

Seaweed anti-obesity tablet hope （页面存档备份，存于互联网档案馆） (BBC - Thermogenin mentioned as part of process)
医学主题词表（MeSH）：thermogenin

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[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000109424 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031710 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Entrez Gene: UCP1 uncoupling protein 1 (mitochondrial, proton carrier). （原始内容存档于2018-10-23）.

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