PAS折叠 |
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![](//images.weserv.nl/?url=//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/FixL_1y28.png/220px-FixL_1y28.png) |
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标志 | PAS |
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Pfam | PF00989(旧版) |
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InterPro | IPR013767 |
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SMART | PAS |
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PROSITE | PDOC50112 |
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SCOP | 2phy / SUPFAM |
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CDD | cd00130 |
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Pfam | 结构(旧版) / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | 结构概要 |
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PDB | 1byw, 1d06, 1d7e, 1dp6, 1dp8, 1dp9, 1drm, 1ew0, 1f98, 1f9i, 1gsv, 1gsw, 1gsx, 1kou, 1ll8, 1lsv, 1lsw, 1lsx, 1lt0, 1mzu, 1nwz, 1odv, 1ot6, 1ot9, 1ota, 1otb, 1otd, 1ote, 1oti, 1s1y, 1s1z, 1s4r, 1s4s, 1s66, 1s67, 1t18, 1t19, 1t1a, 1t1b, 1t1c, 1ts0, 1ts6, 1ts7, 1ts8, 1ugu, 1uwn, 1uwp, 1v9y, 1v9z, 1vb6, 1wa9, 1xfn, 1xfq, 1xj2, 1xj3, 1xj4, 1xj6, 1y28, 2d01, 2d02, 2phy, 2pyp, 2pyr, 3phy, 3pyp |
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PAS结构域(英语:PAS domain)也称为PAS折叠(英语:PAS fold)是一种在细菌、古菌和真核生物中都存在的蛋白质结构域[2]。其功能为检测小分子物质,如检测氧气的EPAS1等[3][4][5]。
参考文献
- ^ PDB 1y28; Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA. A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry. July 2003, 42 (25): 7701–8 [2023-01-04]. PMID 12820879. doi:10.1021/bi0343370. (原始内容存档于2023-01-20).
- ^ Henry, Jonathan T.; Crosson, Sean. Ligand-binding PAS domains in a genomic, cellular, and structural context. Annual Review of Microbiology. 1 January 2011, 65: 261–286. PMC 3298442
. PMID 21663441. doi:10.1146/annurev-micro-121809-151631.
- ^ Liu, Yu C.; Machuca, Mayra A.; Beckham, Simone A.; Gunzburg, Menachem J.; Roujeinikova, Anna. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Acta Crystallographica Section D. 1 October 2015, 71 (10): 2127–2136. PMID 26457436. doi:10.1107/S139900471501384X.
- ^ Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith. Structure and signaling mechanism of Per-ARNT-Sim domains. Structure. 14 October 2009, 17 (10): 1282–1294. PMC 3092527
. PMID 19836329. doi:10.1016/j.str.2009.08.011.
- ^ Hennig, Sven; Strauss, Holger M.; Vanselow, Katja; Yildiz, Özkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim; Wolf, Eva. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLOS Biology. 28 April 2009, 7 (4): e1000094. PMC 2671562
. PMID 19402751. doi:10.1371/journal.pbio.1000094.