胱抑素B
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胱抑素B(英文:Cystatin-B)是一種在人體中由CSTB基因編碼的蛋白質。[6][7]
胱抑素超家族包括含有多個胱抑素樣序列的蛋白質。一些成員是活性半胱氨酸蛋白酶抑制劑,而其他成員已經失去或可能從未獲得這種抑制活性。超家族中有3個抑制家族,包括1型胱抑素(stefin)、2型胱抑素和激肽原。該基因編碼一種作為細胞內半胱氨酸蛋白酶抑制劑而起作用的stefin。胱抑素B能夠形成由非共價作用力穩定的二聚體,抑制木瓜蛋白酶和組織蛋白酶L1、H和B。胱抑素B被認為在防止蛋白酶從溶酶體泄漏方面發揮作用。有證據表明,該基因突變是導致進行性肌陣攣性癲癇患者出現主要缺陷的原因。[7]
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參考文獻
- ^ 與血清胱抑素B相關的疾病;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000160213 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000005054 - Ensembl, May 2017
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- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ 7.0 7.1 Entrez Gene: CSTB cystatin B (stefin B).
- ^ Pavlova, Alona; Björk Ingemar. Grafting of features of cystatins C or B into the N-terminal region or second binding loop of cystatin A (stefin A) substantially enhances inhibition of cysteine proteinases. Biochemistry (United States). Sep 2003, 42 (38): 11326–33. ISSN 0006-2960. PMID 14503883. doi:10.1021/bi030119v.
- ^ Pol, E; Björk I. Role of the single cysteine residue, Cys 3, of human and bovine cystatin B (stefin B) in the inhibition of cysteine proteinases. Protein Sci. (United States). Sep 2001, 10 (9): 1729–38. ISSN 0961-8368. PMC 2253190
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