海他西林
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臨床資料 | |
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商品名 | Hetacin、Versapen |
AHFS/Drugs.com | 藥物獸用信息 |
給藥途徑 | 乳腺注射 |
ATC碼 | |
法律規範狀態 | |
法律規範 | |
識別資訊 | |
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CAS號 | 3511-16-8 ![]() |
PubChem CID | |
DrugBank | |
ChemSpider | |
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KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.020.466 |
化學資訊 | |
化學式 | C19H23N3O4S |
摩爾質量 | 389.47 g·mol−1 |
3D模型(JSmol) | |
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海他西林(英語:Hetacillin)是一種β-內酰胺類抗生素,屬於氨基青黴素家族。它是一種前藥,本身無抗菌活性,[1]但在人體內迅速分解出丙酮,形成氨苄青黴素,[2]對多種細菌均有活性。
給藥
海他西林可以口服。它的鉀鹽,海他西林鉀通過靜脈[3]或肌肉注射給藥。[4]它以商品名Hetacin出售,用於獸醫乳腺注射。[5]
當發現海他西林與氨苄西林相比沒有優勢時,海他西林被撤出市場。[6]
化學
海他西林由氨苄青黴素和丙酮製備而成。在水溶液中它不穩定,在37°C和pH7下半衰期為15至30分鐘,並迅速再次釋放丙酮。[7]
與氨苄西林相反,海他西林僅被細菌酶β-內酰胺酶輕微分解,至少在體外是這樣。
參考資料
- ^ Hetacillin. Drugbank. [2023-03-01]. (原始內容存檔於2016-08-08).
- ^ Sutherland R, Robinson OP. Laboratory and pharmacological studies in man with hetacillin and ampicillin. British Medical Journal. June 1967, 2 (5555): 804–8. PMC 1843140
. PMID 5182358. doi:10.1136/bmj.2.5555.804.
- ^ Tsuji Y, Tomita M. [Clinical effect of intravenous injection of potassium hetacillin (Versapen 'Bristol') on pre- and post-operative infections] (in Japanese). The Japanese Journal of Antibiotics. August 1970, 23 (4): 400–2. PMID 5312791.
- ^ Hara M, Takemoto S, Kawazu T. [Therapeutic experience with intramuscular injection of hetacillin (Versapen 'Bristol') in infection in children] (in Japanese). The Japanese Journal of Antibiotics. December 1970, 23 (5): 482–6. PMID 5314634.
- ^ Hetacin-K Intramammary Infusion for 藥物獸用信息
- ^ Smith JT, Hamilton-Miller J. Hetacillin: A Chemical and Biological Comparison with Ampicillin. Chemotherapy. 1970, 15 (6): 366–78. PMID 5514976. doi:10.1159/000220703.
- ^ Faine S, Harper M. Independent antibiotic actions of hetacillin and ampicillin revealed by fast methods. Antimicrobial Agents and Chemotherapy. January 1973, 3 (1): 15–8. PMC 444353
. PMID 4597707. doi:10.1128/aac.3.1.15.
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