海他西林
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临床资料 | |
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商品名 | Hetacin、Versapen |
AHFS/Drugs.com | 药物兽用信息 |
给药途径 | 乳腺注射 |
ATC码 | |
法律规范状态 | |
法律规范 | |
识别信息 | |
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CAS号 | 3511-16-8 ![]() |
PubChem CID | |
DrugBank | |
ChemSpider | |
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KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.020.466 |
化学信息 | |
化学式 | C19H23N3O4S |
摩尔质量 | 389.47 g·mol−1 |
3D模型(JSmol) | |
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海他西林(英语:Hetacillin)是一种β-内酰胺类抗生素,属于氨基青霉素家族。它是一种前药,本身无抗菌活性,[1]但在人体内迅速分解出丙酮,形成氨苄青霉素,[2]对多种细菌均有活性。
给药
海他西林可以口服。它的钾盐,海他西林钾通过静脉[3]或肌肉注射给药。[4]它以商品名Hetacin出售,用于兽医乳腺注射。[5]
当发现海他西林与氨苄西林相比没有优势时,海他西林被撤出市场。[6]
化学
海他西林由氨苄青霉素和丙酮制备而成。在水溶液中它不稳定,在37°C和pH7下半衰期为15至30分钟,并迅速再次释放丙酮。[7]
与氨苄西林相反,海他西林仅被细菌酶β-内酰胺酶轻微分解,至少在体外是这样。
参考资料
- ^ Hetacillin. Drugbank. [2023-03-01]. (原始内容存档于2016-08-08).
- ^ Sutherland R, Robinson OP. Laboratory and pharmacological studies in man with hetacillin and ampicillin. British Medical Journal. June 1967, 2 (5555): 804–8. PMC 1843140
. PMID 5182358. doi:10.1136/bmj.2.5555.804.
- ^ Tsuji Y, Tomita M. [Clinical effect of intravenous injection of potassium hetacillin (Versapen 'Bristol') on pre- and post-operative infections] (in Japanese). The Japanese Journal of Antibiotics. August 1970, 23 (4): 400–2. PMID 5312791.
- ^ Hara M, Takemoto S, Kawazu T. [Therapeutic experience with intramuscular injection of hetacillin (Versapen 'Bristol') in infection in children] (in Japanese). The Japanese Journal of Antibiotics. December 1970, 23 (5): 482–6. PMID 5314634.
- ^ Hetacin-K Intramammary Infusion for 药物兽用信息
- ^ Smith JT, Hamilton-Miller J. Hetacillin: A Chemical and Biological Comparison with Ampicillin. Chemotherapy. 1970, 15 (6): 366–78. PMID 5514976. doi:10.1159/000220703.
- ^ Faine S, Harper M. Independent antibiotic actions of hetacillin and ampicillin revealed by fast methods. Antimicrobial Agents and Chemotherapy. January 1973, 3 (1): 15–8. PMC 444353
. PMID 4597707. doi:10.1128/aac.3.1.15.
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