蛛毒素受体2

蛛毒素受体2
識別號
别名	ADGRL2；, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
外部ID	OMIM：607018 MGI：2139714 HomoloGene：22712 GeneCards：ADGRL2
基因位置（人类） 染色体 1號染色體 基因座 1p31.1 起始 81,306,147 bp 终止 81,993,932 bp
基因位置（小鼠） 染色体 小鼠3号染色体 基因座 3|3 H3 起始 148,815,583 bp 终止 148,990,555 bp
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • G protein-coupled receptor activity • transmembrane signaling receptor activity • latrotoxin receptor activity • signal transducer activity • carbohydrate binding 細胞組分 • integral component of membrane • 膜 • 胞內 • integral component of plasma membrane • neuron projection 生物學過程 • G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • 訊息傳遞 • adenylate cyclase-activating G protein-coupled receptor signaling pathway • brain development Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	23266	99633
Ensembl	ENSG00000117114	ENSMUSG00000028184
UniProt	O95490	Q8JZZ7
mRNA​序列	NM_001297704 ​NM_001297705 ​NM_001297706 ​NM_012302 ​NM_001330645 ​NM_001350698 ​NM_001350699 ​NM_001366002 ​NM_001366003 ​NM_001366004 ​NM_001366005 ​NM_001366006 ​NM_001366007 ​NM_001366008 ​NM_001366009 ​NM_001393349 ​NM_001393350 ​NM_001393351 ​NM_001393352 ​NM_001393353 ​NM_001393354	NM_001081298
蛋白序列	NP_001284633 ​NP_001284634 ​NP_001284635 ​NP_001317574 ​NP_036434 ​NP_001337627 ​NP_001337628 ​NP_001352931 ​NP_001352932 ​NP_001352933 ​NP_001352934 ​NP_001352935 ​NP_001352936 ​NP_001352937 ​NP_001352938	NP_001074767 ​NP_001392915 ​NP_001392916 ​NP_001392917 ​NP_001392918 ​NP_001392919 ​NP_001392920 ​NP_001392921 ​NP_001392922 ​NP_001392923 ​NP_001392924 ​NP_001392925 ​NP_001392926 ​NP_001392927 ​NP_001392928 ​NP_001392929 ​NP_001392930 ​NP_001392931 ​NP_001392932 ​NP_001392933 ​NP_001392934 ​NP_001392935 ​NP_001392936 ​NP_001392937 ​NP_001392938 ​NP_001392939 ​NP_001392940 ​NP_001392947 ​NP_001392948
基因位置​（UCSC）	Chr 1: 81.31 – 81.99 Mb	Chr 3: 148.82 – 148.99 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

蛛毒素受体2（英语：Latrophilin 2）是一种在人类中由ADGRL2基因编码的蛋白质。

该基因编码G蛋白偶联受体（GPCR）的蛛毒素受体亚家族成员。蛛毒素受体可能在细胞黏附和信号转导中发挥作用。在非人类物种的实验中，富含半胱氨酸的GPS（G蛋白偶联受体蛋白水解位点）结构域内的内源性蛋白水解切割产生两个亚基（一个大的细胞外N末端细胞黏附亚基和一个与GPCR的促胰液素/降钙素家族具有实质相似性的亚基）非共价结合在细胞膜上。虽然已经描述了几种转录变体，但仅确定了其中一种的生物学有效性。

参见

• 黏附G蛋白偶联受体

延申阅读

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• White GR, Varley JM, Heighway J. Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene. Dec 1998, 17 (26): 3513–9. PMID 10030676. doi:10.1038/sj.onc.1202487 . 
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. The Journal of Biological Chemistry. Oct 2000, 275 (42): 32387–90. PMID 10964907. doi:10.1074/jbc.C000490200 . 
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• Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE. Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biology. 2007, 8 (4): R64. PMC 1896007 . PMID 17456239. doi:10.1186/gb-2007-8-4-r64.