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酮啡诺

维基百科,自由的百科全书
酮啡诺
臨床資料
ATC碼
  • 未分配
识别信息
  • 17-(Cyclopropylmethyl)-4-hydroxymorphinan-6-one
CAS号79798-39-3
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C20H25NO2
摩尔质量311.43 g·mol−1
3D模型(JSmol英语JSmol
  • C1CC1CN2CCC34CC(=O)CCC3C2CC5=C4C(=CC=C5)O
  • InChI=1S/C20H25NO2/c22-15-6-7-16-17-10-14-2-1-3-18(23)19(14)20(16,11-15)8-9-21(17)12-13-4-5-13/h1-3,13,16-17,23H,4-12H2/t16-,17+,20-/m0/s1
  • Key:ORMBBVGVPWUEMQ-QKLQHJQFSA-N

酮啡诺INN:ketorfanol;开发代号:SBW-22)是一种吗啡喃家族的阿片类镇痛药,在动物试验中被发现具有“有效的抗扭体活性”,但从未上市。[1][2]它是吗啡喃的17-环烷基甲基衍生物,因此在结构上与布托啡诺英语Butorphanol赛克罗酚奥昔啡烷英语Oxilorphan普罗啡烷英语Proxorphan佐尔啡诺英语Xorphanol密切相关,它们优先充当κ-阿片受体激动剂,并在较小程度上充当μ-阿片受体部分激动剂/拮抗剂[3]

参考资料

  1. ^ Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 2014-11-14: 720–. ISBN 978-1-4757-2085-3. 
  2. ^ Korolkovas A. Essentials of Medicinal Chemistry. Wiley. 1988-08-16: 243. ISBN 978-0-471-88356-2. 
  3. ^ Neumeyer JL, Bidlack JM, Zong R, Bakthavachalam V, Gao P, Cohen DJ, et al. Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. Journal of Medicinal Chemistry. January 2000, 43 (1): 114–22. PMID 10633042. doi:10.1021/jm9903343.