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酮啡諾

維基百科,自由的百科全書
酮啡諾
臨床資料
ATC碼
  • 未分配
識別資訊
  • 17-(Cyclopropylmethyl)-4-hydroxymorphinan-6-one
CAS號79798-39-3
PubChem CID
ChemSpider
UNII
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C20H25NO2
摩爾質量311.43 g·mol−1
3D模型(JSmol英語JSmol
  • C1CC1CN2CCC34CC(=O)CCC3C2CC5=C4C(=CC=C5)O
  • InChI=1S/C20H25NO2/c22-15-6-7-16-17-10-14-2-1-3-18(23)19(14)20(16,11-15)8-9-21(17)12-13-4-5-13/h1-3,13,16-17,23H,4-12H2/t16-,17+,20-/m0/s1
  • Key:ORMBBVGVPWUEMQ-QKLQHJQFSA-N

酮啡諾INN:ketorfanol;開發代號:SBW-22)是一種嗎啡喃家族的阿片類鎮痛藥,在動物試驗中被發現具有「有效的抗扭體活性」,但從未上市。[1][2]它是嗎啡喃的17-環烷基甲基衍生物,因此在結構上與布托啡諾英語Butorphanol賽克羅酚奧昔啡烷英語Oxilorphan普羅啡烷英語Proxorphan佐爾啡諾英語Xorphanol密切相關,它們優先充當κ-阿片受體激動劑,並在較小程度上充當μ-阿片受體部分激動劑/拮抗劑[3]

參考資料

  1. ^ Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 2014-11-14: 720–. ISBN 978-1-4757-2085-3. 
  2. ^ Korolkovas A. Essentials of Medicinal Chemistry. Wiley. 1988-08-16: 243. ISBN 978-0-471-88356-2. 
  3. ^ Neumeyer JL, Bidlack JM, Zong R, Bakthavachalam V, Gao P, Cohen DJ, et al. Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. Journal of Medicinal Chemistry. January 2000, 43 (1): 114–22. PMID 10633042. doi:10.1021/jm9903343.