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BNL 1ME A.7R.1

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BNL 1ME A.7R.1小鼠腫瘤細胞系,最初是正常小鼠胚胎的非致瘤性肝上皮細胞BNL CL.2,經過致癌的甲基膽蒽 (3-methylcholanthrene) 誘導後轉化而建立的[1]。新建立的細胞與BNL CL.2細胞相比,E-鈣粘蛋白信使核糖核酸和蛋白水平均顯著降低,而骨髓間質標記物和相關轉錄因子的表達水平則提高[2]。新建立的細胞可以在0.3%的瓊脂培養基中生長及增殖,並且對鼠痘病毒陰性。有科學家將此癌細胞通過外科手術直接植入近交野生型BALB/c小鼠肝臟,希望能夠闡明固體器官癌轉移的生物學機制[3]。有研究指出生育三烯酚英语Tocotrienol能夠降低BNL 1ME A.7R.1細胞的活性,並且導致細胞凋亡[4]

參考資料

  1. ^ Patek, PQ; Collins, JL; Cohn, M. Transformed cell lines susceptible or resistant to in vivo surveillance against tumorigenesis.. Nature. 1978-11-30, 276 (5687): 510–1 [2019-12-08]. PMID 723934. doi:10.1038/276510a0. 
  2. ^ Oh, J; Kwak, JH; Kwon, DY; Kim, AY; Oh, DS; Je, NK; Lee, J; Jung, YS. Transformation of Mouse Liver Cells by Methylcholanthrene Leads to Phenotypic Changes Associated with Epithelial-mesenchymal Transition.. Toxicological research. 2014-12, 30 (4): 261–6 [2019-12-08]. PMID 25584145. doi:10.5487/TR.2014.30.4.261. 
  3. ^ Das, DK; Durojaiye, V; Ilboudo, A; Naidoo, MK; Ogunwobi, O. A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis.. Journal of visualized experiments : JoVE. 2015-10-24, (105): e52858 [2019-12-08]. PMID 26555484. doi:10.3791/52858. 
  4. ^ Har, CH; Keong, CK. Effects of tocotrienols on cell viability and apoptosis in normal murine liver cells (BNL CL.2) and liver cancer cells (BNL 1ME A.7R.1), in vitro.. Asia Pacific journal of clinical nutrition. 2005, 14 (4): 374–80 [2019-12-08]. PMID 16326644. 

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