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PER2

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PER2
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名PER2;, FASPS, FASPS1, period circadian clock 2, period circadian regulator 2
外部IDOMIM603426 MGI1195265 HomoloGene7885 GeneCardsPER2
相关疾病
advanced sleep phase syndrome[1]
基因位置(人类
2号染色体
染色体2号染色体[2]
2号染色体
PER2的基因位置
PER2的基因位置
基因座2q37.3起始238,244,044 bp[2]
终止238,290,102 bp[2]
RNA表达模式


查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_003894
​NM_022817

NM_011066

蛋白序列

NP_073728

NP_035196

基因位置​(UCSC)Chr 2: 238.24 – 238.29 MbChr 1: 91.34 – 91.39 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

PER2是由人类基因per2 编码的蛋白质,与昼夜节律有关[6][7],是黑腹果蝇 Period 基因在哺乳动物基因组中的同源物[8]

参考文献

  1. ^ 與PER2相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000132326 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000055866 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–9. PMID 9427249. S2CID 10059149. doi:10.1016/S0896-6273(00)80417-1可免费查阅. 
  7. ^ Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. Jan 2007, 128 (1): 59–70. PMC 1828903可免费查阅. PMID 17218255. doi:10.1016/j.cell.2006.11.043. 
  8. ^ Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–1269. PMID 9427249. S2CID 10059149. doi:10.1016/s0896-6273(00)80417-1可免费查阅. 

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