MALAT-1 （英语：metastasis associated lung adenocarcinoma transcript 1 的缩写，也称为NEAT2 ，noncoding nuclear-enriched abundant transcript 2 ）是一个长链非编码RNA 基因 ，表达于细胞核 ，在哺乳动物 中高度保守[ 3] 选择性剪接 、DNA的表观遗传 修饰等细胞中的多种反应，可控制参与肿瘤远端转移 的基因表达[ 4] 糖尿病 与癌症 等多种疾病有关[ 5] [ 6] [ 7] [ 8]
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl , May 2017^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB, Chess A. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains . BMC Genomics. 2007, 8 : 39. PMC 1800850 PMID 17270048 doi:10.1186/1471-2164-8-39 ^ Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells . Cancer Research. February 2013, 73 (3): 1180–1189. PMC 3589741 PMID 23243023 doi:10.1158/0008-5472.CAN-12-2850 ^ Wu Y, Huang C, Meng X, Li J. Long Noncoding RNA MALAT1: Insights into its Biogenesis and Implications in Human Disease. Current Pharmaceutical Design. 2015, 21 (34): 5017–5028. PMID 26205289 doi:10.2174/1381612821666150724115625 ^ Yoshimoto R, Mayeda A, Yoshida M, Nakagawa S. MALAT1 long non-coding RNA in cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. January 2016, 1859 (1): 192–199. PMID 26434412 doi:10.1016/j.bbagrm.2015.09.012 ^ Tian X, Xu G. Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis . BMJ Open. 2015, 5 (9): e008653. PMC 4593150 PMID 26423854 doi:10.1136/bmjopen-2015-008653 ^ Wei Y, Niu B. Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis . Disease Markers. 2015, 2015 : 164635. PMC 4572489 PMID 26420912 doi:10.1155/2015/164635
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