奴芬克索

編輯連結
維基百科，自由的百科全書
奴芬克索
識別資訊
  • 2-[3-(2-azabicyclo[2.2.2]octan-2-yl)-1,1-diphenylpropyl]-5-methyl-1,3,4-oxadiazole
CAS號57726-65-5
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)
化學資訊
化學式C25H29N3O
摩爾質量387.53 g·mol−1
3D模型（JSmol（英語：JSmol））
  • CC1=NN=C(O1)C(CCN2CC3CCC2CC3)(C4=CC=CC=C4)C5=CC=CC=C5
  • InChI=1S/C25H29N3O/c1-19-26-27-24(29-19)25(21-8-4-2-5-9-21,22-10-6-3-7-11-22)16-17-28-18-20-12-14-23(28)15-13-20/h2-11,20,23H,12-18H2,1H3
  • Key:CVOCKGAVXLCEGM-UHFFFAOYSA-N

奴芬克索（INN：nufenoxole；開發代號：SC-27166）是一種止瀉藥，作為外周選擇性阿片受體激動劑，作用方式與洛哌丁胺類似。雖然它能夠激活μ-阿片受體，但它無法穿過血腦屏障，因此具有選擇性的抗腹瀉作用，而不產生鎮痛作用。[1][2][3][4][5]

參見

參考資料

  1. ^ US RE29556E,Adelstein GW,「1,1-Diaryl-1-oxadiazol-alkylamines」,發行於28 February 1978,指定於G.D. Searle & Company 
  2. ^ Dajani EZ, Bianchi RG, East PF, Bloss JL, Adelstein GW, Yen CH. The pharmacology of SC-27166: a novel antidiarrheal agent. The Journal of Pharmacology and Experimental Therapeutics. December 1977, 203 (3): 512–26. PMID 411912. 
  3. ^ Mackerer CR, Brougham LR, East PF, Bloss JL, Dajani EZ, Clay GA. Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain and myenteric plexus. The Journal of Pharmacology and Experimental Therapeutics. December 1977, 203 (3): 527–38. PMID 200732. 
  4. ^ Niemegeers CJ, McGuire JL, Heykants JJ, Janssen PA. Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs. The Journal of Pharmacology and Experimental Therapeutics. September 1979, 210 (3): 327–33. PMID 480185. 
  5. ^ Korey A, Zilm DH, Sellers EM. Dependence liability of two antidiarrheals, nufenoxole and loperamide. Clinical Pharmacology and Therapeutics. May 1980, 27 (5): 659–64. PMID 7371363. S2CID 35222789. doi:10.1038/clpt.1980.93. 
取自「https://zh.wikipedia.org/w/index.php?title=奴芬克索&oldid=81809987」