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E2F1

維基百科,自由的百科全書
E2F transcription factor 1
PDB rendering based on 2aze.
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 E2F1; E2F-1; RBAP1; RBBP3; RBP3
擴展標識 遺傳學189971 鼠基因101941 同源基因3828 ChEMBL: 4382 GeneCards: E2F1 Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 1869 13555
Ensembl ENSG00000101412 ENSMUSG00000027490
UniProt Q01094 Q61501
mRNA序列 NM_005225 NM_007891
蛋白序列 NP_005216 NP_031917
基因位置 Chr 20:
32.26 – 32.27 Mb
Chr 2:
154.56 – 154.57 Mb
PubMed查詢 [1] [2]

轉錄因子E2F1是由人類E2F1基因編碼出的蛋白質[1]

該基因編碼出的蛋白質是E2F轉錄因子家族中的成員。E2F家族在控制細胞周期及抑癌基因功能上起到重要作用,也是小DNA致癌病毒轉化蛋白的靶點。E2F家族中的多個成員蛋白包含許多進化保守的結構域。這些結構域包括:DNA結合域、與受分化調控的轉錄因子蛋白(DP)之間相互作用的二聚化結構域、富含酸性胺基酸的轉活化結構域以及位於轉活化結構域中的抑癌蛋白關聯結構域。該蛋白與其他兩個成員E2F2及E2F3具有額外的周期蛋白結合結構域。該蛋白以細胞周期依賴性的模式優先與視網膜母細胞瘤蛋白pRB結合。它可以同時介導細胞增殖及p53-依賴/非依賴的細胞凋亡[2]

轉錄

E2F1的啟動子區有PAX8轉錄因子的結合序列,可促進E2F1的轉錄[3]

相互作用

E2F1與下列蛋白具有相互作用NCOA6[4]視網膜母細胞瘤樣蛋白1[5]視網膜母細胞瘤蛋白[5][6][7][8][9][10][11]GTF2H1[12]SKP2[13] PURA,[14]NPDC1[15]Sp2轉錄因子[16]Sp1轉錄因子[16][17][18]CUL1[13] ARID3A,[19]TOPBP1[20][21]周期蛋白A1[22]TP53BP1[8]周期蛋白A2[23]Sp4轉錄因子[16]Sp3轉錄因子[16]抗增殖蛋白[24][25][26][27]NDN[11][28]MDM4[29] TFDP1[10][19][30][31]泛素C[32]

另見

參考文獻

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  2. ^ Entrez Gene: E2F1 E2F transcription factor 1. (原始內容存檔於2019-10-16). 
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  16. ^ 16.0 16.1 16.2 16.3 Rotheneder, H; Geymayer S, Haidweger E. Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. J. Mol. Biol. (ENGLAND). November 1999, 293 (5): 1005–15. ISSN 0022-2836. PMID 10547281. doi:10.1006/jmbi.1999.3213. 
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  19. ^ 19.0 19.1 Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K. A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. Oncogene (ENGLAND). August 1998, 17 (7): 853–65. ISSN 0950-9232. PMID 9780002. doi:10.1038/sj.onc.1202163. 
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  22. ^ Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032可免費查閱. PMID 10022926. 
  23. ^ Xu, M; Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. (UNITED STATES). December 1994, 14 (12): 8420–31. ISSN 0270-7306. PMC 359381可免費查閱. PMID 7969176. 
  24. ^ Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P. A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem. Biophys. Res. Commun. (United States). December 2003, 312 (2): 459–66. ISSN 0006-291X. PMID 14637159. doi:10.1016/j.bbrc.2003.10.148. 
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  26. ^ Wang, Sheng; Zhang Baohua, Faller Douglas V. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. (England). June 2002, 21 (12): 3019–28. ISSN 0261-4189. PMC 126057可免費查閱. PMID 12065415. doi:10.1093/emboj/cdf302. 
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  28. ^ Kuwako, Ken-ichiro; Taniura Hideo, Yoshikawa Kazuaki. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J. Biol. Chem. (United States). January 2004, 279 (3): 1703–12. ISSN 0021-9258. PMID 14593116. doi:10.1074/jbc.M308454200. 
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PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells.[永久失效連結]

深入閱讀

  • Dupont E, Sansal I, Toru D; et al. [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]. C. R. Seances Soc. Biol. Fil. 1997, 191 (1): 95–104. PMID 9181131. 
  • Stevens C, La Thangue NB. The emerging role of E2F-1 in the DNA damage response and checkpoint control.. DNA Repair (Amst.). 2005, 3 (8-9): 1071–9. PMID 15279795. doi:10.1016/j.dnarep.2004.03.034. 
  • Zhang Z, Wang H, Li M; et al. Novel MDM2 p53-independent functions identified through RNA silencing technologies.. Ann. N. Y. Acad. Sci. 2006, 1058 (1): 205–14. PMID 16394138. doi:10.1196/annals.1359.030. 
  • Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G. PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells. Mol. Carcinog. July 2009, 48 (12): 1149–58. PMID 19603422. doi:10.1002/mc.20569. 

外部連結

E2F1引用了美國國家醫學圖書館提供的資料,這些資料屬於公共領域