5-(2-氨基丙基)吲哚
臨床資料 | |
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给药途径 | 口服 |
ATC碼 |
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法律規範狀態 | |
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识别信息 | |
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CAS号 | 3784-30-3 |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.236.959 |
化学信息 | |
化学式 | C11H14N2 |
摩尔质量 | 174.25 g·mol−1 |
3D模型(JSmol) | |
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5-(2-氨基丙基)吲哚(5-API, 5-IT, PAL-571)[1]是一种具有移情作用的吲哚/苯乙胺衍生物,最初由艾伯特·霍夫曼于1962年报道。[2]它是一种狡詐家藥物,自2011年以来,它以娛樂性用藥在网上销售。[3]
它是一种三元单胺释放剂,EC50值为12.9 nM(多巴胺)、13.3 nM(去甲肾上腺素)、104.8 nM(血清素),也是一种MAO-A抑制剂。[4][5]
参考文献
- ^ Banks ML, Bauer CT, Blough BE, Rothman RB, Partilla JS, Baumann MH, Negus SS. Abuse-related effects of dual dopamine/serotonin releasers with varying potency to release norepinephrine in male rats and rhesus monkeys. Experimental and Clinical Psychopharmacology. June 2014, 22 (3): 274–284. PMC 4067459 . PMID 24796848. doi:10.1037/a0036595.
- ^ FR 1344579,Hofmann, Albert; Troxler, Franz,「Nouveaux derives de l'indole et leur preparation」
- ^ Katselou M, Papoutsis I, Nikolaou P, Spiliopoulou C, Athanaselis S. 5-(2-aminopropyl)indole: a new player in the drama of 'legal highs' alerts the community. Drug and Alcohol Review. January 2015, 34 (1): 51–7. PMID 24634984. doi:10.1111/dar.12136 .
- ^ Marusich JA, Antonazzo KR, Blough BE, Brandt SD, Kavanagh PV, Partilla JS, Baumann MH. The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue. Neuropharmacology. February 2016, 101: 68–75. PMC 4681602 . PMID 26362361. doi:10.1016/j.neuropharm.2015.09.004.
- ^ Herraiz T, Brandt SD. 5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO). Drug Testing and Analysis. July–August 2014, 6 (7–8): 607–13. PMID 24115740. doi:10.1002/dta.1530. hdl:10261/102667.