凝溶胶蛋白

Gelsolin; 凝溶胶蛋白
	PDB rendering based on 1c0f.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1C0F, 1C0G, 1D4X, 1DEJ, 1EQY, 1ESV, 1H1V, 1KCQ, 1MDU, 1NLV, 1NM1, 1NMD, 1P8X, 1P8Z, 1SOL, 1T44, 1YAG, 1YVN, 2FF3, 2FF6, 2FH1, 2FH2, 2FH3, 2FH4, 3A5L, 3A5M, 3A5N, 3A5O, 3CI5, 3CIP, 3CJB, 3CJC, 3FFK, 3FFN, 3TU5
标识
代号	GSN; ADF; AGEL
扩展标识	遗传学：137350 鼠基因：95851 同源基因：147 GeneCards: GSN Gene
基因本体论描述
分子功能	· actin binding; · calcium ion binding; · protein binding;
细胞成分	· ruffle; · extracellular region; · extracellular space; · cytosol; · actin cytoskeleton; · lamellipodium; · protein complex; · perinuclear region of cytoplasm; · extracellular vesicular exosome;
生物过程	· apoptotic process; · cellular component disassembly involved in execution phase of apoptosis; · aging; · oligodendrocyte development; · vesicle-mediated transport; · actin filament polymerization; · regulation of cell adhesion; · tissue regeneration; · response to ethanol; · phosphatidylinositol-mediated signaling; · actin filament severing; · barbed-end actin filament capping; · response to folic acid; · cilium morphogenesis; · cellular response to cadmium ion;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
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凝溶胶蛋白（英語：Gelsolin）是一种肌动蛋白结合蛋白，是肌动蛋白丝装配和解聚调节的关键。凝溶胶蛋白是肌动蛋白结合蛋白中凝溶胶蛋白/绒毛蛋白（英语：villin）超家族的重要成员^[1]。凝溶胶蛋白表达于细胞内（在细胞质基质和线粒体）以及细胞外（血浆）^[2]。

结构

凝溶胶蛋白是一个82千道尔顿的蛋白质，具有六个同源亚结构域，称为S1-S6。每个亚结构域都包含有五片β折叠，旁边缀有两个α螺旋，一个垂直，另一个平行于β折叠片。其N端（S1-S3）和C端（S4-S6）各自组成了一个额外的β折叠^[3]。

^ Sun HQ, Yamamoto M, Mejillano M, Yin HL. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. November 1999, 274 (47): 33179–82. PMID 10559185. doi:10.1074/jbc.274.47.33179.
^ Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J. Biol. Chem. May 2000, 275 (20): 15343–9. PMID 10809769. doi:10.1074/jbc.275.20.15343.
^ Kiselar JG, Janmey PA, Almo SC, Chance MR. Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proc. Natl. Acad. Sci. U.S.A. April 2003, 100 (7): 3942–7. PMC 153027 . PMID 12655044. doi:10.1073/pnas.0736004100.