MYO5A

MYO5A
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4J5L、4LX1、4LX2、4LLI、4D07
識別號
别名	MYO5A；, GS1, MYH12, MYO5, MYR12, myosin VA
外部ID	OMIM：160777 MGI：105976 HomoloGene：20100 GeneCards：MYO5A
基因位置（人类）
染色体	15號染色體
终止	52,529,132 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	75,130,970 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• calcium ion binding; • 核苷酸結合; • calmodulin binding; • microfilament motor activity; • actin binding; • cytoskeletal motor activity; • ATP結合; • RNA binding; • 无序域特异性结合; • 相同蛋白质结合; • 血浆蛋白结合; • actin filament binding;
細胞組分	• 細胞質; • recycling endosome; • 囊泡; • 细胞质基质; • 晚期内吞体; • 高尔基体; • 膜; • 生长锥; • ruffle; • 黑色素体; • insulin-responsive compartment; • photoreceptor outer segment; • 过氧化物酶体; • secretory granule; • microtubule plus-end; • filopodium tip; • neuronal cell body; • 早期内吞体; • 内质网; • 微丝; • neuron projection; • 溶酶体; • actomyosin; • 中间纤维; • 外排體; • myosin complex; • unconventional myosin complex; • smooth endoplasmic reticulum; • postsynapse; • glutamatergic synapse;
生物學過程	• regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; • melanin biosynthetic process; • synapse organization; • insulin secretion; • secretory granule localization; • melanosome localization; • actin filament-based movement; • post-Golgi vesicle-mediated transport; • odontogenesis; • endoplasmic reticulum localization; • melanin metabolic process; • regulation of Golgi organization; • long-chain fatty acid biosynthetic process; • melanosome transport; • cellular response to insulin stimulus; • vesicle transport along actin filament; • protein transport; • developmental pigmentation; • 髓鞘形成; • 色素沉着; • protein localization to plasma membrane; • melanocyte differentiation; • locomotion involved in locomotory behavior; • vesicle-mediated transport; • 視覺; • 胞吐作用; • 化学性突触传递; • hair follicle maturation; • transport; • establishment of endoplasmic reticulum localization to postsynapse; • regulation of postsynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
直系同源
	4644
	17918
	ENSG00000197535
	ENSMUSG00000034593
	Q9Y4I1
	Q99104
	NM_000259; NM_001142495; NM_001382347; NM_001382348; NM_001382349
	NM_010864
	NP_000250; NP_001135967; NP_001369276; NP_001369277; NP_001369278
	NP_034994
	維基數據
檢視/編輯人類	檢視/編輯小鼠

MYO5A是一个位于人类15号染色体上的基因，编码一种隶属肌凝蛋白超家族的非典型的肌凝蛋白肌凝蛋白-Va（Myosin-Ia）。肌凝蛋白-Va与细胞内囊泡、细胞器，以及蛋白复合体通过微丝纤维运输有关^[5]^[6]^[7]^[8]^[9]^[10]。

参见

肌凝蛋白

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197535 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034593 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Velvarska, Hana; Niessing, Dierk. Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c. PLOS ONE. 2013-12-10, 8 (12): e82065. Bibcode:2013PLoSO...882065V. ISSN 1932-6203. PMC 3858360 . PMID 24339992. doi:10.1371/journal.pone.0082065.
^ Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons. The Journal of Biological Chemistry. 2011-04-22, 286 (16): 14352–14361. ISSN 0021-9258. PMC 3077635 . PMID 21349835. doi:10.1074/jbc.M110.187286.
^ Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circulation Research. 2014-03-14, 114 (6): 982–992. ISSN 0009-7330. PMC 4213814 . PMID 24508725. doi:10.1161/CIRCRESAHA.114.302711.
^ Engle LJ, Kennett RH. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics. Feb 1994, 19 (3): 407–16. PMID 8188282. doi:10.1006/geno.1994.1088.
^ Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549.
^ Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).

这是一篇與生物化學相關的小作品。你可以通过编辑或修订扩充其内容。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197535 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034593 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Velvarska, Hana; Niessing, Dierk. Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c. PLOS ONE. 2013-12-10, 8 (12): e82065. Bibcode:2013PLoSO...882065V. ISSN 1932-6203. PMC 3858360 . PMID 24339992. doi:10.1371/journal.pone.0082065.

[:1-6] Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons. The Journal of Biological Chemistry. 2011-04-22, 286 (16): 14352–14361. ISSN 0021-9258. PMC 3077635 . PMID 21349835. doi:10.1074/jbc.M110.187286.

[:2-7] Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. Circulation Research. 2014-03-14, 114 (6): 982–992. ISSN 0009-7330. PMC 4213814 . PMID 24508725. doi:10.1161/CIRCRESAHA.114.302711.

[pmid8188282-8] Engle LJ, Kennett RH. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics. Feb 1994, 19 (3): 407–16. PMID 8188282. doi:10.1006/geno.1994.1088.

[pmid8022818-9] Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings of the National Academy of Sciences of the United States of America. Jul 1994, 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. PMC 44240 . PMID 8022818. doi:10.1073/pnas.91.14.6549.

[entrez-10] Entrez Gene: MYO5A myosin VA (heavy chain 12, myoxin).

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]