痕量胺相關受體
痕量胺相關受體（英語：Trace amine-associated receptors，簡稱TAAR，有時也稱trace amine receptors）是一種G蛋白偶聯受體，於2001年發現。[1][2][3]其中，人類身上六個功能性痕量胺相關受體中的第一個，TAAR1，因為是痕量胺的內源受體這一獨特功能而在醫學界、製藥研究方面備受矚目——痕量胺是苯丙氨酸和色氨酸以及苯丙胺、甲基苯丙胺等興奮劑的痕量代謝產物。[4][5][6][7][8][9]2004年的一份研究顯示，哺乳動物的TAAR1也是甲狀腺激素的脫羧碘化代謝產物。[6] 脊椎動物的TAAR2至TAAR9也可用作嗅覺受器，探測揮發性胺。[10]
參考資料
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- ^ Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, Olson SB, Magenis RE, Amara SG, Grandy DK. Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol. Pharmacol. 2001, 60 (6): 1181–8. PMID 11723224. doi:10.1124/mol.60.6.1181.
- ^ Miller GM. The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J. Neurochem. January 2011, 116 (2): 164–176. PMC 3005101 . PMID 21073468. doi:10.1111/j.1471-4159.2010.07109.x.
- ^ Lam VM, Espinoza S, Gerasimov AS, Gainetdinov RR, Salahpour A. In-vivo pharmacology of Trace-Amine Associated Receptor 1. Eur. J. Pharmacol. June 2015, 763: 136–42. PMID 26093041. doi:10.1016/j.ejphar.2015.06.026.
- ^ 6.0 6.1 Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. doi:10.1038/nm1051.
- ^ Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol. Sci. 2005, 26 (5): 274–81. PMID 15860375. doi:10.1016/j.tips.2005.03.007.
- ^ Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.
- ^ Grandy DK. Trace amine-associated receptor 1-Family archetype or iconoclast?. Pharmacol. Ther. 2007, 116 (3): 355–390. PMC 2767338 . PMID 17888514. doi:10.1016/j.pharmthera.2007.06.007.
- ^ Liberles SD. Trace amine-associated receptors: ligands, neural circuits, and behaviors. Curr. Opin. Neurobiol. October 2015, 34: 1–7. PMID 25616211. doi:10.1016/j.conb.2015.01.001.
