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催产素酶

维基百科,自由的百科全书

催产素酶Oxytocinase)是一种可以代谢催产素[1]。最著名的催产素酶是Leucyl-cystinyl氨肽酶英语leucyl/cystinyl aminopeptidase[1][2],本身也是脑啡肽酶,已知也有其他的催产素酶[1][3]。怀孕时,催产素酶可以平衡催产素的浓度,因为随着胎儿成长,胎儿分泌的催产素会增加,催产素酶会分解胎儿分泌的催产素,以维持平衡[2]。有研究发现催产素酶的浓度会随胎龄渐渐增加,直到分娩为止,因此胎儿的发育可以用催产素酶浓度进行评估[4]

抑制剂

阿吗他定英语Amastatin短整合蛋白英语lebestatin(ubenimex)及嘌呤霉素英语puromycin都可以抑制催产素的代谢,不过他们也会抑制其他多肽(像是后叶加压素甲硫脑素英语met-enkephalin强啡肽英语dynorphin A等)的分解,[5][3][6]EDTA、L-甲硫氨酸邻二氮菲磷酸阿米酮英语phosphoramidon也会抑制催产素的代谢[7]

相关条目

参考资料

  1. ^ 1.0 1.1 1.2 Tsujimoto M, Hattori A. The oxytocinase subfamily of M1 aminopeptidases. Biochim. Biophys. Acta. 2005, 1751 (1): 9–18. PMID 16054015. doi:10.1016/j.bbapap.2004.09.011. 
  2. ^ 2.0 2.1 Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S. Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy. Biochim. Biophys. Acta. 2005, 1751 (1): 19–25. PMID 15894523. doi:10.1016/j.bbapap.2005.04.006. 
  3. ^ 3.0 3.1 Mizutani S, Yokosawa H, Tomoda Y. Degradation of oxytocin by the human placenta: effect of selective inhibitors. Acta Endocrinol. 1992, 127 (1): 76–80. PMID 1355623. doi:10.1530/acta.0.1270076. 
  4. ^ Klimek, Marek. Comparative analysis of ACTH and oxytocinase plasma concentration during pregnancy. Neuro Endocrinology Letters. August 2005, 26 (4): 337–341. ISSN 0172-780X. PMID 16136013. 
  5. ^ Meisenberg G, Simmons WH. Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice. Peptides. 1984, 5 (3): 535–9. PMID 6540873. doi:10.1016/0196-9781(84)90083-4. 
  6. ^ Stancampiano R, Melis MR, Argiolas A. Proteolytic conversion of oxytocin by brain synaptic membranes: role of aminopeptidases and endopeptidases. Peptides. 1991, 12 (5): 1119–25. PMID 1800950. doi:10.1016/0196-9781(91)90068-z. 
  7. ^ Itoh C, Watanabe M, Nagamatsu A, Soeda S, Kawarabayashi T, Shimeno H. Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization. Biol. Pharm. Bull. 1997, 20 (1): 20–4. PMID 9013800. doi:10.1248/bpb.20.20.