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催产素酶

维基百科,自由的百科全书

催产素酶Oxytocinase)是一種可以代謝催产素[1]。最著名的催产素酶是Leucyl-cystinyl氨肽酶英语leucyl/cystinyl aminopeptidase[1][2],本身也是腦啡肽酶,已知也有其他的催产素酶[1][3]。懷孕時,催产素酶可以平衡催产素的濃度,因為隨著胎兒成長,胎兒分泌的催产素會增加,催产素酶會分解胎兒分泌的催产素,以維持平衡[2]。有研究發現催产素酶的濃度會隨胎齡漸漸增加,直到分娩為止,因此胎兒的發育可以用催产素酶濃度進行評估[4]

抑制劑

阿嗎他定英语Amastatin短整合蛋白英语lebestatin(ubenimex)及嘌呤霉素英语puromycin都可以抑制催产素的代謝,不過他們也會抑制其他多肽(像是後葉加壓素甲硫腦素英语met-enkephalin強啡肽英语dynorphin A等)的分解,[5][3][6]EDTA、L-甲硫氨酸邻二氮菲磷酸阿米酮英语phosphoramidon也會抑制催产素的代謝[7]

相關條目

參考資料

  1. ^ 1.0 1.1 1.2 Tsujimoto M, Hattori A. The oxytocinase subfamily of M1 aminopeptidases. Biochim. Biophys. Acta. 2005, 1751 (1): 9–18. PMID 16054015. doi:10.1016/j.bbapap.2004.09.011. 
  2. ^ 2.0 2.1 Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S. Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy. Biochim. Biophys. Acta. 2005, 1751 (1): 19–25. PMID 15894523. doi:10.1016/j.bbapap.2005.04.006. 
  3. ^ 3.0 3.1 Mizutani S, Yokosawa H, Tomoda Y. Degradation of oxytocin by the human placenta: effect of selective inhibitors. Acta Endocrinol. 1992, 127 (1): 76–80. PMID 1355623. doi:10.1530/acta.0.1270076. 
  4. ^ Klimek, Marek. Comparative analysis of ACTH and oxytocinase plasma concentration during pregnancy. Neuro Endocrinology Letters. August 2005, 26 (4): 337–341. ISSN 0172-780X. PMID 16136013. 
  5. ^ Meisenberg G, Simmons WH. Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice. Peptides. 1984, 5 (3): 535–9. PMID 6540873. doi:10.1016/0196-9781(84)90083-4. 
  6. ^ Stancampiano R, Melis MR, Argiolas A. Proteolytic conversion of oxytocin by brain synaptic membranes: role of aminopeptidases and endopeptidases. Peptides. 1991, 12 (5): 1119–25. PMID 1800950. doi:10.1016/0196-9781(91)90068-z. 
  7. ^ Itoh C, Watanabe M, Nagamatsu A, Soeda S, Kawarabayashi T, Shimeno H. Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization. Biol. Pharm. Bull. 1997, 20 (1): 20–4. PMID 9013800. doi:10.1248/bpb.20.20.